Intraarterial Platelet Infusion for Patients with Intractable Gastrointestinal Hemorrhage and Severe Refractory Thrombocytopenia

David C. Madoff, Michael J. Wallace, Benjamin Lichtiger, Krishna V. Komanduri, William A. Ross, Aida B. Narvios, C. Lee Parmley

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Transarterial therapies used for the treatment of acute nonvariceal gastrointestinal (GI) hemorrhage have traditionally included vasopressin infusion and embolization. However, for patients with diffuse or multifocal hemorrhage and severe refractory thrombocytopenia, these options are suboptimal because platelet counts and coagulation parameters may not be adequate to allow for the formation of a stable clot. Herein two such patients treated with direct intraarterial (IA) infusion of platelets into the vascular territory supplying the hemorrhage are described. In both patients, after IA platelet infusion, blood product requirements were immediately reduced, bleeding from the GI tract resolved by clinical and laboratory criteria, and no significant bowel ischemia was seen.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalJournal of Vascular and Interventional Radiology
Volume15
Issue number4
DOIs
StatePublished - Apr 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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