Intra-aortic balloon counterpulsation

a treatment for ischaemic stroke?

B. I. Tranmer, C. Peniston, R. Iacobacci, Tomas Salerno, A. R. Hudson

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Intra-aortic balloon counterpulsation (IABC) augments cardiac output (CO) and pulse pressure (PP) allowing patients with low output heart failure to be supported for a period of time. Augmentation of CO and PP may also be beneficial to the patient with acute cerebral ischaemia. In this paper we investigated the possibility of using IABC to increase local cerebral blood flow (CBF) in ischaemic brain. In 12 anaesthetized mongrel dogs, a canine stroke model was produced by occluding the left internal carotid and middle cerebral arteries with aneurysm clips. Six dogs were then treated with IABC for 2 h, and 6 other dogs acted as control (no IABC). Haemodynamic data were measured continuously and CBF (microsphere technique) and CO measurements were performed pre- and post-occlusion, and then twice during the treatment period. In the IABC-treated animals, PP increased from 32±5.9 to 39±7.8 mmHg (p<0.01) but CO and local CBF in the ischaemic brain did not change significantly during IABC. However, in 4 dogs with significant increases in CO due to IABC [1.7±0.3 to 2.8±0.7 l/min (p<0.05)], local CBF in ischaemic brain also increased significantly from 22±12 to 26±11 cc/100 g/min (p<0.05). In the control animals, CO and local CBF did not change significantly during the observation period. These data suggest that augmentation of CO and PP by IABC results in an increase in local CBF in ischaemic brain. IABC may be an effective treatment for ischaemic stroke in those patients with compromised cardiac performance whose cardiac output and pulse pressure can be augmented by IABC.

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalNeurological Research
Volume11
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Counterpulsation
Cerebrovascular Circulation
Cardiac Output
Stroke
Dogs
Blood Pressure
Therapeutics
Brain
Intracranial Aneurysm
Brain Ischemia
Microspheres
Surgical Instruments
Canidae
Arterial Pressure
Heart Failure
Hemodynamics
Observation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Tranmer, B. I., Peniston, C., Iacobacci, R., Salerno, T., & Hudson, A. R. (1989). Intra-aortic balloon counterpulsation: a treatment for ischaemic stroke? Neurological Research, 11(2), 109-113.

Intra-aortic balloon counterpulsation : a treatment for ischaemic stroke? / Tranmer, B. I.; Peniston, C.; Iacobacci, R.; Salerno, Tomas; Hudson, A. R.

In: Neurological Research, Vol. 11, No. 2, 01.01.1989, p. 109-113.

Research output: Contribution to journalArticle

Tranmer, BI, Peniston, C, Iacobacci, R, Salerno, T & Hudson, AR 1989, 'Intra-aortic balloon counterpulsation: a treatment for ischaemic stroke?', Neurological Research, vol. 11, no. 2, pp. 109-113.
Tranmer BI, Peniston C, Iacobacci R, Salerno T, Hudson AR. Intra-aortic balloon counterpulsation: a treatment for ischaemic stroke? Neurological Research. 1989 Jan 1;11(2):109-113.
Tranmer, B. I. ; Peniston, C. ; Iacobacci, R. ; Salerno, Tomas ; Hudson, A. R. / Intra-aortic balloon counterpulsation : a treatment for ischaemic stroke?. In: Neurological Research. 1989 ; Vol. 11, No. 2. pp. 109-113.
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