In a previous report, the contribution of intra-abdominal fluid collections to the morbidity and mortality of clinical pancreas transplantation was reviewed. In this more recent series, the development of intra-abdominal fluid collections in the ED group (12%) is much improved over the 33% (19 of 57 cases, P = .05) in the comparable group. And the results in the BD group (19%) are not statistically different from those of the ED group. Graft loss rates and overall graft function are approximately equal in both groups. The highest rate of graft funtion is seen in the LRD subset of the ED group, and is most likely due to the favorable immunologic relationship between donor and recipient. The improvement in cadaver graft survival seen in the BD group is probably due to the capacity to detect (via a decrease in the urine amylase) and treat graft rejection, prior to a change in the blood sugar. We ascribe the improvement in the rate of intra-abdominal fluid collections seen in both drainage groups to (1) the institution of prophylactic perioperative triple antibiotic therapy, and (2) changes in the donor operation, including suture ligation of peri-pancreatic lymphatic channels, and in the cadaver whole pancreas with duodenum graft, povidine-iodine irrigation of the donor duodenum.
|Original language||English (US)|
|Number of pages||2|
|Issue number||1 SUPPL. 1|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas