Intestinal transplantation for the treatment of neoplastic disease

Jang I. Moon, Gennaro Selvaggi, Seigo Nishida, David M. Levi, Tomoaki Kato, Phillip Ruiz, Pablo Bejarano, Juan R. Madariaga, Andreas G. Tzakis

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: Authors reviewed single center experience of intestinal transplantation for treatment of intra-abdominal neoplastic disease. Methods: There were 25 auto- or allograft transplantations in 21 patients; desmoid tumor (14), neuroendocrine tumor (2), adenocarcinoma (2), hemangioma (1), lymphoma (1), and solid pseudopapillary tumor (1). Medical records were reviewed for cause of graft loss and mortality, recurrent neoplasm, and quality of life. Survival was analyzed using Kaplan-Meier method. Results: There were 11 graft losses; mortality with functioning graft (6), ischemic necrosis (2), acute or chronic rejection (2), and arterial thrombosis (1) during 38 months of mean follow-up. Seven patients died because of recurrent neoplasm and transplant related complications. Six patients experienced recurrent disease; three desmoid tumor (3/14), two adenocarcinoma (2/2), and one neuroendocrine tumor (1/2). Recurrent desmoid tumors were successfully treated with simple excision. Patient and graft survival in the desmoid tumor are 69.2% and 50.0% at 5 years after transplant. Among 14 survivors, 2 need parenteral nutrition or intravenous hydration. Twelve patients are working full time. Conclusions: Intestinal transplantation is a reasonable life-saving treatment for catastrophic intra-abdominal neoplastic diseases.

Original languageEnglish
Pages (from-to)284-291
Number of pages8
JournalJournal of Surgical Oncology
Volume92
Issue number4
DOIs
StatePublished - Dec 15 2005

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Aggressive Fibromatosis
Transplantation
Transplants
Neoplasms
Neuroendocrine Tumors
Therapeutics
Adenocarcinoma
Mortality
Parenteral Nutrition
Autografts
Graft Survival
Hemangioma
Medical Records
Allografts
Survivors
Lymphoma
Thrombosis
Necrosis
Quality of Life
Survival

Keywords

  • Allograft
  • Autograft
  • Desmoid tumor
  • Intestinal transplantation
  • Neuroendocrine tumor

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Intestinal transplantation for the treatment of neoplastic disease. / Moon, Jang I.; Selvaggi, Gennaro; Nishida, Seigo; Levi, David M.; Kato, Tomoaki; Ruiz, Phillip; Bejarano, Pablo; Madariaga, Juan R.; Tzakis, Andreas G.

In: Journal of Surgical Oncology, Vol. 92, No. 4, 15.12.2005, p. 284-291.

Research output: Contribution to journalArticle

Moon, JI, Selvaggi, G, Nishida, S, Levi, DM, Kato, T, Ruiz, P, Bejarano, P, Madariaga, JR & Tzakis, AG 2005, 'Intestinal transplantation for the treatment of neoplastic disease', Journal of Surgical Oncology, vol. 92, no. 4, pp. 284-291. https://doi.org/10.1002/jso.20416
Moon, Jang I. ; Selvaggi, Gennaro ; Nishida, Seigo ; Levi, David M. ; Kato, Tomoaki ; Ruiz, Phillip ; Bejarano, Pablo ; Madariaga, Juan R. ; Tzakis, Andreas G. / Intestinal transplantation for the treatment of neoplastic disease. In: Journal of Surgical Oncology. 2005 ; Vol. 92, No. 4. pp. 284-291.
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