Intestinal transplantation for short bowel syndrome secondary to gastroschisis

Motoshi Wada, Tomoaki Kato, Yutaka Hayashi, Gennaro Selvaggi, N. Mittal, J. Thompson, M. Gonzalez, Seigo Nishida, J. Madariaga, A. Tzakis

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background/Purpose: Gastroschisis is the most frequent cause of pediatric intestinal transplantation. This study reviews our experience of intestinal transplantation secondary to gastroschisis to elucidate those factors affecting the outcome of children with short bowel syndrome. Methods: A retrospective review was performed for children who underwent intestinal transplantation for gastroschisis at the University of Miami between June 2003 and August 1994. Results: Thirty-two transplants were performed in 28 children with gastroschisis during the study period. Associated intestinal anomalies were present in 22 infants (atresia [n = 14], volvulus [n = 3], and/or ischemia [n = 16]). Spontaneous prenatal closure of gastroschisis, a rare anomaly associated with bowel atresia and ischemia because of a very small abdominal defect, was seen in 9 patients. Most of the patients had a complicated course and required multiple abdominal surgeries before transplant. Fifteen (53.6%) patients are currently alive at a median follow-up of 23.5 months. Short-term survival rate has significantly improved in recent years. Conclusions: Patients with complex gastroschisis and intestinal anomalies have a significant risk for progression to short bowel syndrome. Intestinal transplantation can be a lifesaving option and provides a satisfactory outcome for children with short bowel syndrome secondary to gastroschisis.

Original languageEnglish
Pages (from-to)1841-1845
Number of pages5
JournalJournal of Pediatric Surgery
Volume41
Issue number11
DOIs
StatePublished - Nov 1 2006

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Gastroschisis
Short Bowel Syndrome
Transplantation
Ischemia
Transplants
Intestinal Volvulus
Survival Rate
Pediatrics

Keywords

  • Gastroschisis
  • Intestinal transplantation
  • Short-bowel syndrome

ASJC Scopus subject areas

  • Surgery

Cite this

Intestinal transplantation for short bowel syndrome secondary to gastroschisis. / Wada, Motoshi; Kato, Tomoaki; Hayashi, Yutaka; Selvaggi, Gennaro; Mittal, N.; Thompson, J.; Gonzalez, M.; Nishida, Seigo; Madariaga, J.; Tzakis, A.

In: Journal of Pediatric Surgery, Vol. 41, No. 11, 01.11.2006, p. 1841-1845.

Research output: Contribution to journalArticle

Wada, M, Kato, T, Hayashi, Y, Selvaggi, G, Mittal, N, Thompson, J, Gonzalez, M, Nishida, S, Madariaga, J & Tzakis, A 2006, 'Intestinal transplantation for short bowel syndrome secondary to gastroschisis', Journal of Pediatric Surgery, vol. 41, no. 11, pp. 1841-1845. https://doi.org/10.1016/j.jpedsurg.2006.06.010
Wada, Motoshi ; Kato, Tomoaki ; Hayashi, Yutaka ; Selvaggi, Gennaro ; Mittal, N. ; Thompson, J. ; Gonzalez, M. ; Nishida, Seigo ; Madariaga, J. ; Tzakis, A. / Intestinal transplantation for short bowel syndrome secondary to gastroschisis. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 11. pp. 1841-1845.
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