TY - JOUR
T1 - Intestinal metaplasia of the gallbladder
T2 - A morphologic and immunocytochemical study
AU - Albores-Saavedra, Jorge
AU - Nadji, Mehrdad
AU - Henson, Donald E.
AU - Ziegels-Weissman, Jocelyne
AU - Mones, Joan M.
N1 - Funding Information:
Although intestinal metaplasia of tile gallbladder is relatively common, only sporadic investigations of the morphologic and fnnctional characteristics of this condition have been pnblished. I-3 The metaplastic change is known to be focal, may involve any part of the gallbladder, and may occur in association with cholelithiasis, congenital anomalies, adenomas, and carcinomas. 4 Histologically, intestinal metaplasia is characterized by the appearance of cells with intestinal phenotypes, such as goblet cells, absorptive columnar cells, and Paneth cells. With silver stains, both argyrophil and argentaffin cells have also been identified. 9,5-7 These various cell types are usually found in different proportions, ahhough goblet cells predominate. Based on the ultrastructural morphology of their granules, the endocrine cells have been classified as enterochromaffin (EC) cells and enterochromaffin-like (ECL) cells. 8 However, only a few im-munohistologic studies trove been concerned with the secretory products of these endocrine cells. 9 Received from the *Department of Pathology, University of Miami Jackson Memorial Medical Center, and the tCommunity Oncology and Rehabilitation Branch, National Cancer Institute Bethesda, Maryland. Revision accepted for publication November 25, 1985. Supported by clinical fellowship award 5954 from the American Cancer Society (J.M.M.).
PY - 1986/6
Y1 - 1986/6
N2 - The morphologic spectrum of intestinal metaplasia was studied in 49 gallbladders that had been excised because of cholelithiasis. Based on the absence or presence of endocrine cells, the cases of intestinal metaplasia were arbitrarily divided into two groups. The gallbladders from the first group (26 cases) contained isolated or small clusters of mature goblet cells, while those from the second group (23 cases), in addition to the goblet cells, contained argyrophil and argentaffin cells and, less frequently, Paneth cells and gland-like structures similar to colonic crypts. Pseudopyloric glands and superficial gastric-type epithelium were present in both groups. Argyrophil cells outnumbered argentaffin cells by a ratio of 4 to 1. By immunocytochemical methods serotonin-containing cells were found to be the most common endocrine cells. Other endocrine cells showed immunoreactivity for somatostatin, cholecystokinin, gastrin, and pancreatic polypeptide. The presence of gut endocrine cells and Paneth cells in the pseudopyloric glands suggests that these glands are also an integral component of intestinal metaplasia of the gallbladder. The findings support the hypothesis that cholelithiasis induces the appearance of a stem endodermal cell that, in turn, may differentiate into cells with mature intestinal or gastric phenotypes.
AB - The morphologic spectrum of intestinal metaplasia was studied in 49 gallbladders that had been excised because of cholelithiasis. Based on the absence or presence of endocrine cells, the cases of intestinal metaplasia were arbitrarily divided into two groups. The gallbladders from the first group (26 cases) contained isolated or small clusters of mature goblet cells, while those from the second group (23 cases), in addition to the goblet cells, contained argyrophil and argentaffin cells and, less frequently, Paneth cells and gland-like structures similar to colonic crypts. Pseudopyloric glands and superficial gastric-type epithelium were present in both groups. Argyrophil cells outnumbered argentaffin cells by a ratio of 4 to 1. By immunocytochemical methods serotonin-containing cells were found to be the most common endocrine cells. Other endocrine cells showed immunoreactivity for somatostatin, cholecystokinin, gastrin, and pancreatic polypeptide. The presence of gut endocrine cells and Paneth cells in the pseudopyloric glands suggests that these glands are also an integral component of intestinal metaplasia of the gallbladder. The findings support the hypothesis that cholelithiasis induces the appearance of a stem endodermal cell that, in turn, may differentiate into cells with mature intestinal or gastric phenotypes.
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U2 - 10.1016/S0046-8177(86)80134-4
DO - 10.1016/S0046-8177(86)80134-4
M3 - Article
C2 - 2872152
AN - SCOPUS:0022632920
VL - 17
SP - 614
EP - 620
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 6
ER -