Intestinal metaplasia of the gallbladder

A morphologic and immunocytochemical study

Jorge Albores-Saavedra, Mehrdad Nadji, Donald E. Henson, Jocelyne Ziegels-Weissman, Joan M. Mones

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The morphologic spectrum of intestinal metaplasia was studied in 49 gallbladders that had been excised because of cholelithiasis. Based on the absence or presence of endocrine cells, the cases of intestinal metaplasia were arbitrarily divided into two groups. The gallbladders from the first group (26 cases) contained isolated or small clusters of mature goblet cells, while those from the second group (23 cases), in addition to the goblet cells, contained argyrophil and argentaffin cells and, less frequently, Paneth cells and gland-like structures similar to colonic crypts. Pseudopyloric glands and superficial gastric-type epithelium were present in both groups. Argyrophil cells outnumbered argentaffin cells by a ratio of 4 to 1. By immunocytochemical methods serotonin-containing cells were found to be the most common endocrine cells. Other endocrine cells showed immunoreactivity for somatostatin, cholecystokinin, gastrin, and pancreatic polypeptide. The presence of gut endocrine cells and Paneth cells in the pseudopyloric glands suggests that these glands are also an integral component of intestinal metaplasia of the gallbladder. The findings support the hypothesis that cholelithiasis induces the appearance of a stem endodermal cell that, in turn, may differentiate into cells with mature intestinal or gastric phenotypes.

Original languageEnglish
Pages (from-to)614-620
Number of pages7
JournalHuman Pathology
Volume17
Issue number6
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Endocrine Cells
Metaplasia
Gallbladder
Enterochromaffin Cells
Paneth Cells
Goblet Cells
Cholelithiasis
Enteroendocrine Cells
Pancreatic Polypeptide
Cholecystokinin
Gastrins
Gastric Mucosa
Somatostatin
Serotonin
Stomach
Stem Cells
Epithelium
Phenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Intestinal metaplasia of the gallbladder : A morphologic and immunocytochemical study. / Albores-Saavedra, Jorge; Nadji, Mehrdad; Henson, Donald E.; Ziegels-Weissman, Jocelyne; Mones, Joan M.

In: Human Pathology, Vol. 17, No. 6, 01.01.1986, p. 614-620.

Research output: Contribution to journalArticle

Albores-Saavedra, J, Nadji, M, Henson, DE, Ziegels-Weissman, J & Mones, JM 1986, 'Intestinal metaplasia of the gallbladder: A morphologic and immunocytochemical study', Human Pathology, vol. 17, no. 6, pp. 614-620. https://doi.org/10.1016/S0046-8177(86)80134-4
Albores-Saavedra, Jorge ; Nadji, Mehrdad ; Henson, Donald E. ; Ziegels-Weissman, Jocelyne ; Mones, Joan M. / Intestinal metaplasia of the gallbladder : A morphologic and immunocytochemical study. In: Human Pathology. 1986 ; Vol. 17, No. 6. pp. 614-620.
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