Intestinal and multivisceral transplantation

Tomoaki Kato, Phillip Ruiz, John F. Thompson, Lon B. Eskind, Deborah Weppler, Farrukh A. Khan, Antonio D. Pinna, Jose R. Nery, Andreas G. Tzakis

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations

Abstract

Intestinal transplantation has been gradually instituted in the management of intestinal failure. More than 200 cases including isolated intestinal transplant, liver/intestinal transplant, and multivisceral transplant have been performed worldwide, with 1-year graft and patient survival rates of 66% and 54%, respectively. Indications for the procedure include short bowel syndrome and functional abnormalities secondary to a variety of diseases or conditions. Tacrolimus-based immunosuppression regimens have been used universally with improved outcomes. The major contributors to the morbidity and mortality include rejection, infection, and technical complications. Of those, control of rejection remains the most difficult dilemma and it will be the key to improved patient and graft survival.

Original languageEnglish (US)
Pages (from-to)226-237
Number of pages12
JournalWorld Journal of Surgery
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2002

ASJC Scopus subject areas

  • Surgery

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