Interstitial lung disease (ILD) and severe ITP

Vincenzo Fontana, Lawrence L. Horstman, Elio Donna, Pamela Dudkiewicz, Eugene R Ahn, Yeon S. Ahn

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Introduction: Platelets play an important role in inflammatory and immune responses. We report interstitial lung disease (ILD) developing during the acute phase of severe thrombocytopenia in 3 patients with severe refractory ITP. Methods and Results: We identified 3 cases with severe ITP who developed ILD in the course of refractory chronic ITP. The thrombocytopenia was severe in all cases. ILD was an incidental finding at the presentation and often misdiagnosed as lung infections. ILD was documented by lung biopsy in cases 1 and 2, supplemented by serial chest X-rays and/or CAT scan. As the ITP improved, ILD regressed in case 1, persisted in case 2, and progressed to advanced pulmonary fibrosis in case 3. Conclusion: We report an association of ILD with severe refractory ITP. ILD was detected in acute phase of platelet destruction, suggesting that platelet destruction may have triggered inflammation in the lung, leading to ILD.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalHematology
Volume12
Issue number1
DOIs
StatePublished - Feb 1 2007

Keywords

  • Idiopathic thrombocytopenic purpura (ITP)
  • Interstitial lung disease (ILD)
  • Platelets in inflammation
  • Pulmonary fibrosis

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Interstitial lung disease (ILD) and severe ITP'. Together they form a unique fingerprint.

Cite this