Interstitial hydrostatic pressures in patients undergoing CABG and valve replacement

F. J. Menninger, Eliot Rosenkranz, J. R. Utley, W. P. Dembitsky, A. R. Hargens, R. M. Peters

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Using the Scholander-Hargens wick technique to measure interstitial fluid hydrostatic pressure (IFP) in thigh muscle (MIP) and subcutaneous tissue (SQIP), we have studied 12 patients undergoing cardiopulmonary bypass (CPB). Simultaneous measurements were made of serum total proteins (TP) and colloid osmotic pressure (COP). Bypass was carried out with a nonblood, noncolloid prime. In the postoperative period, colloid and blood were given which raised COP above prebypass levels (see Table II). MIP rises more with hemodilution than does SQIP and is less negative throughout. MIP rises faster when COP drops than does SQIP. These findings suggest that subcutaneous tissue interstitial space is loose and has a high compliance, whereas muscular tissue interstitial space is tight and has a low compliance. The increased pressure represents increase in fluid which is then removed promptly as COP is restored in the postoperative period. Experimental studies in animals show a response similar to MIP in the myocardium.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume79
Issue number2
StatePublished - Mar 28 1980
Externally publishedYes

Fingerprint

Hydrostatic Pressure
Colloids
Osmotic Pressure
Subcutaneous Tissue
Postoperative Period
Compliance
Hemodilution
Extracellular Fluid
Thigh
Cardiopulmonary Bypass
Blood Proteins
Myocardium
Pressure
Muscles

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Menninger, F. J., Rosenkranz, E., Utley, J. R., Dembitsky, W. P., Hargens, A. R., & Peters, R. M. (1980). Interstitial hydrostatic pressures in patients undergoing CABG and valve replacement. Journal of Thoracic and Cardiovascular Surgery, 79(2), 181-187.

Interstitial hydrostatic pressures in patients undergoing CABG and valve replacement. / Menninger, F. J.; Rosenkranz, Eliot; Utley, J. R.; Dembitsky, W. P.; Hargens, A. R.; Peters, R. M.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 79, No. 2, 28.03.1980, p. 181-187.

Research output: Contribution to journalArticle

Menninger, FJ, Rosenkranz, E, Utley, JR, Dembitsky, WP, Hargens, AR & Peters, RM 1980, 'Interstitial hydrostatic pressures in patients undergoing CABG and valve replacement', Journal of Thoracic and Cardiovascular Surgery, vol. 79, no. 2, pp. 181-187.
Menninger, F. J. ; Rosenkranz, Eliot ; Utley, J. R. ; Dembitsky, W. P. ; Hargens, A. R. ; Peters, R. M. / Interstitial hydrostatic pressures in patients undergoing CABG and valve replacement. In: Journal of Thoracic and Cardiovascular Surgery. 1980 ; Vol. 79, No. 2. pp. 181-187.
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