Interstitial fluid pressure changes during cardiopulmonary bypass

Eliot Rosenkranz, J. R. Utley, F. J. Menninger, W. P. Dembitsky, A. R. Hargens, R. M. Peters

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The effects of cardiopulmonary bypass using hemodilution on interstitial fluid pressure were measured using the Scholander wick technique. In 10 mongrel dogs, interstitial fluid pressure was measured in subcutaneous tissue, skeletal muscle, stomach, and left ventricle before and during 2 hours of cardiopulmonary bypass. Changes in interstitial fluid pressure were correlated with plasma colloidal osmotic pressure and duration of bypass. In subcutaneous tissue and skeletal muscle, interstitial fluid pressure increased during bypass; it did not change in the stomach. End-diastolic interstitial fluid pressure in the left ventricle increased significantly. These increases in pressure were presumably due to an increase in interstitial water. The rise in interstitial fluid pressure acts to partially neutralize the fall in plasma colloidal osmotic pressure.

Original languageEnglish
Pages (from-to)536-542
Number of pages7
JournalAnnals of Thoracic Surgery
Volume30
Issue number6
DOIs
StatePublished - Dec 1 1980
Externally publishedYes

Fingerprint

Extracellular Fluid
Cardiopulmonary Bypass
Pressure
Subcutaneous Tissue
Osmotic Pressure
Heart Ventricles
Skeletal Muscle Ventricle
Stomach
Hemodilution
Skeletal Muscle
Dogs
Water

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Rosenkranz, E., Utley, J. R., Menninger, F. J., Dembitsky, W. P., Hargens, A. R., & Peters, R. M. (1980). Interstitial fluid pressure changes during cardiopulmonary bypass. Annals of Thoracic Surgery, 30(6), 536-542. https://doi.org/10.1016/S0003-4975(10)61727-4

Interstitial fluid pressure changes during cardiopulmonary bypass. / Rosenkranz, Eliot; Utley, J. R.; Menninger, F. J.; Dembitsky, W. P.; Hargens, A. R.; Peters, R. M.

In: Annals of Thoracic Surgery, Vol. 30, No. 6, 01.12.1980, p. 536-542.

Research output: Contribution to journalArticle

Rosenkranz, E, Utley, JR, Menninger, FJ, Dembitsky, WP, Hargens, AR & Peters, RM 1980, 'Interstitial fluid pressure changes during cardiopulmonary bypass', Annals of Thoracic Surgery, vol. 30, no. 6, pp. 536-542. https://doi.org/10.1016/S0003-4975(10)61727-4
Rosenkranz, Eliot ; Utley, J. R. ; Menninger, F. J. ; Dembitsky, W. P. ; Hargens, A. R. ; Peters, R. M. / Interstitial fluid pressure changes during cardiopulmonary bypass. In: Annals of Thoracic Surgery. 1980 ; Vol. 30, No. 6. pp. 536-542.
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