Interstitial deletion of 8(q13q22) in diffuse large B-cell gastric lymphoma

Yao-Shan Fan, Kamilia Rizkalla, Jay Engel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man. Low-grade MALT lymphoma was not seen in the sections submitted for examination. Helicobactor pylori organisms were found in a biopsy performed prior to resection of the tumor. The karyotype was described as 45,X,-Y,del(8)(q13q22). No rearrangement between chromosome 8 and others was detected with fluorescence in situ hybridization using a whole chromosome 8 painting probe. Fluorescence in situ hybridization with the C-MYC gene showed its normal location at 8q24 on both chromosomes 8 without rearrangement. Amplification of C-MYC was not detected in interphase cells. Deletion of 8q may represent a unique genomic alteration in this particular subtype of primary gastric lymphoma. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume115
Issue number1
DOIs
StatePublished - Nov 1 1999
Externally publishedYes

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Chromosomes, Human, Pair 8
B-Cell Lymphoma
Fluorescence In Situ Hybridization
Non-Hodgkin's Lymphoma
Chromosome Painting
Marginal Zone B-Cell Lymphoma
Pylorus
Interphase
Lymphoid Tissue
Karyotype
Stomach
Mucous Membrane
B-Lymphocytes
Biopsy
Familial primary gastric lymphoma
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Interstitial deletion of 8(q13q22) in diffuse large B-cell gastric lymphoma. / Fan, Yao-Shan; Rizkalla, Kamilia; Engel, Jay.

In: Cancer Genetics and Cytogenetics, Vol. 115, No. 1, 01.11.1999, p. 28-31.

Research output: Contribution to journalArticle

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