Abstract
An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man. Low-grade MALT lymphoma was not seen in the sections submitted for examination. Helicobactor pylori organisms were found in a biopsy performed prior to resection of the tumor. The karyotype was described as 45,X,-Y,del(8)(q13q22). No rearrangement between chromosome 8 and others was detected with fluorescence in situ hybridization using a whole chromosome 8 painting probe. Fluorescence in situ hybridization with the C-MYC gene showed its normal location at 8q24 on both chromosomes 8 without rearrangement. Amplification of C-MYC was not detected in interphase cells. Deletion of 8q may represent a unique genomic alteration in this particular subtype of primary gastric lymphoma. Copyright (C) 1999 Elsevier Science Inc.
| Original language | English |
|---|---|
| Pages (from-to) | 28-31 |
| Number of pages | 4 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 115 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 1 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Interstitial deletion of 8(q13q22) in diffuse large B-cell gastric lymphoma. / Fan, Yao-Shan; Rizkalla, Kamilia; Engel, Jay.
In: Cancer Genetics and Cytogenetics, Vol. 115, No. 1, 01.11.1999, p. 28-31.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interstitial deletion of 8(q13q22) in diffuse large B-cell gastric lymphoma
AU - Fan, Yao-Shan
AU - Rizkalla, Kamilia
AU - Engel, Jay
PY - 1999/11/1
Y1 - 1999/11/1
N2 - An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man. Low-grade MALT lymphoma was not seen in the sections submitted for examination. Helicobactor pylori organisms were found in a biopsy performed prior to resection of the tumor. The karyotype was described as 45,X,-Y,del(8)(q13q22). No rearrangement between chromosome 8 and others was detected with fluorescence in situ hybridization using a whole chromosome 8 painting probe. Fluorescence in situ hybridization with the C-MYC gene showed its normal location at 8q24 on both chromosomes 8 without rearrangement. Amplification of C-MYC was not detected in interphase cells. Deletion of 8q may represent a unique genomic alteration in this particular subtype of primary gastric lymphoma. Copyright (C) 1999 Elsevier Science Inc.
AB - An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man. Low-grade MALT lymphoma was not seen in the sections submitted for examination. Helicobactor pylori organisms were found in a biopsy performed prior to resection of the tumor. The karyotype was described as 45,X,-Y,del(8)(q13q22). No rearrangement between chromosome 8 and others was detected with fluorescence in situ hybridization using a whole chromosome 8 painting probe. Fluorescence in situ hybridization with the C-MYC gene showed its normal location at 8q24 on both chromosomes 8 without rearrangement. Amplification of C-MYC was not detected in interphase cells. Deletion of 8q may represent a unique genomic alteration in this particular subtype of primary gastric lymphoma. Copyright (C) 1999 Elsevier Science Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033231265&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033231265&partnerID=8YFLogxK
U2 - 10.1016/S0165-4608(99)00078-3
DO - 10.1016/S0165-4608(99)00078-3
M3 - Article
C2 - 10565296
AN - SCOPUS:0033231265
VL - 115
SP - 28
EP - 31
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 1
ER -