Interstitial deletion of 8(q13q22) in diffuse large B-cell gastric lymphoma

Yao Shan Fan, Kamilia Rizkalla, Jay Engel

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

An interstitial deletion in the long arm of chromosome 8 as the sole structural anomaly was detected in a primary gastric diffuse large B-cell lymphoma, high-grade mucosa-associated lymphoid tissue (MALT) type, from a 74-year-old man. Low-grade MALT lymphoma was not seen in the sections submitted for examination. Helicobactor pylori organisms were found in a biopsy performed prior to resection of the tumor. The karyotype was described as 45,X,-Y,del(8)(q13q22). No rearrangement between chromosome 8 and others was detected with fluorescence in situ hybridization using a whole chromosome 8 painting probe. Fluorescence in situ hybridization with the C-MYC gene showed its normal location at 8q24 on both chromosomes 8 without rearrangement. Amplification of C-MYC was not detected in interphase cells. Deletion of 8q may represent a unique genomic alteration in this particular subtype of primary gastric lymphoma. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume115
Issue number1
DOIs
StatePublished - Nov 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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