Interrelationship between Schwann cell function and extracellular matrix production

Richard P. Bunge; Mary B Bunge

doi:10.1016/0166-2236(83)90235-7

Interrelationship between Schwann cell function and extracellular matrix production

Richard P. Bunge, Mary B Bunge

Research output: Contribution to journal › Article

100 Citations (Scopus)

Abstract

Schwann cells that envelop axons resemble epithelial cells in that they form a cellular boundary that has a foothold on basal lamina; this lamina separates the Schwann cell-axon units from the endoneurial extracellular matrix (ECM) components. Also like epithelial cells, it has been found recently (by using unique culture preparations) that Schwann cells manufacture ECM constituents. Moreover, secretion and also assembly of ECM components (which may induce polarization of the Schwann cell) are required for the development of normal Schwann cell function. Schwann cell secretion and perturbations in secretion that interfere with the expression of Schwann cell function are reviewed here.

Original language	English
Pages (from-to)	499-505
Number of pages	7
Journal	Trends in Neurosciences
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/0166-2236(83)90235-7
State	Published - Jan 1 1983
Externally published	Yes

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Schwann Cells

Extracellular Matrix

Axons

Epithelial Cells

Basement Membrane

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Bunge, R. P., & Bunge, M. B. (1983). Interrelationship between Schwann cell function and extracellular matrix production. Trends in Neurosciences, 6(C), 499-505. https://doi.org/10.1016/0166-2236(83)90235-7

Interrelationship between Schwann cell function and extracellular matrix production. / Bunge, Richard P.; Bunge, Mary B.

In: Trends in Neurosciences, Vol. 6, No. C, 01.01.1983, p. 499-505.

Research output: Contribution to journal › Article

Bunge, RP & Bunge, MB 1983, 'Interrelationship between Schwann cell function and extracellular matrix production', Trends in Neurosciences, vol. 6, no. C, pp. 499-505. https://doi.org/10.1016/0166-2236(83)90235-7

Bunge RP, Bunge MB. Interrelationship between Schwann cell function and extracellular matrix production. Trends in Neurosciences. 1983 Jan 1;6(C):499-505. https://doi.org/10.1016/0166-2236(83)90235-7

Bunge, Richard P. ; Bunge, Mary B. / Interrelationship between Schwann cell function and extracellular matrix production. In: Trends in Neurosciences. 1983 ; Vol. 6, No. C. pp. 499-505.

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10.1016/0166-2236(83)90235-7