Interrater agreement for diagnosis of Alzheimer's disease

The MIRAGE study

L. A. Farrer, L. A. Cupples, S. Blackburn, D. K. Kiely, S. Auerbach, J. H. Growdon, L. Connor-Lacke, H. Karlinsky, A. Thibert, J. R. Burke, C. Utley, H. Chui, A. Ireland, R. Duara, Roberto Lopez Alberola, E. B. Larson, S. O'Connell, W. A. Kukull

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 ± 0.13) when the subjects were grouped as 'AD' (probable or possible) versus 'not AD,' but somewhat lower (0.52 ± 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.

Original languageEnglish
Pages (from-to)652-656
Number of pages5
JournalNeurology
Volume44
Issue number4
StatePublished - Apr 1 1994

Fingerprint

Alzheimer Disease
Memory Disorders
Multicenter Studies
Comorbidity
Epidemiologic Studies
Research Personnel

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Farrer, L. A., Cupples, L. A., Blackburn, S., Kiely, D. K., Auerbach, S., Growdon, J. H., ... Kukull, W. A. (1994). Interrater agreement for diagnosis of Alzheimer's disease: The MIRAGE study. Neurology, 44(4), 652-656.

Interrater agreement for diagnosis of Alzheimer's disease : The MIRAGE study. / Farrer, L. A.; Cupples, L. A.; Blackburn, S.; Kiely, D. K.; Auerbach, S.; Growdon, J. H.; Connor-Lacke, L.; Karlinsky, H.; Thibert, A.; Burke, J. R.; Utley, C.; Chui, H.; Ireland, A.; Duara, R.; Lopez Alberola, Roberto; Larson, E. B.; O'Connell, S.; Kukull, W. A.

In: Neurology, Vol. 44, No. 4, 01.04.1994, p. 652-656.

Research output: Contribution to journalArticle

Farrer, LA, Cupples, LA, Blackburn, S, Kiely, DK, Auerbach, S, Growdon, JH, Connor-Lacke, L, Karlinsky, H, Thibert, A, Burke, JR, Utley, C, Chui, H, Ireland, A, Duara, R, Lopez Alberola, R, Larson, EB, O'Connell, S & Kukull, WA 1994, 'Interrater agreement for diagnosis of Alzheimer's disease: The MIRAGE study', Neurology, vol. 44, no. 4, pp. 652-656.
Farrer LA, Cupples LA, Blackburn S, Kiely DK, Auerbach S, Growdon JH et al. Interrater agreement for diagnosis of Alzheimer's disease: The MIRAGE study. Neurology. 1994 Apr 1;44(4):652-656.
Farrer, L. A. ; Cupples, L. A. ; Blackburn, S. ; Kiely, D. K. ; Auerbach, S. ; Growdon, J. H. ; Connor-Lacke, L. ; Karlinsky, H. ; Thibert, A. ; Burke, J. R. ; Utley, C. ; Chui, H. ; Ireland, A. ; Duara, R. ; Lopez Alberola, Roberto ; Larson, E. B. ; O'Connell, S. ; Kukull, W. A. / Interrater agreement for diagnosis of Alzheimer's disease : The MIRAGE study. In: Neurology. 1994 ; Vol. 44, No. 4. pp. 652-656.
@article{b6ac2b2026d4401b8535ac1aaab16881,
title = "Interrater agreement for diagnosis of Alzheimer's disease: The MIRAGE study",
abstract = "There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 ± 0.13) when the subjects were grouped as 'AD' (probable or possible) versus 'not AD,' but somewhat lower (0.52 ± 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.",
author = "Farrer, {L. A.} and Cupples, {L. A.} and S. Blackburn and Kiely, {D. K.} and S. Auerbach and Growdon, {J. H.} and L. Connor-Lacke and H. Karlinsky and A. Thibert and Burke, {J. R.} and C. Utley and H. Chui and A. Ireland and R. Duara and {Lopez Alberola}, Roberto and Larson, {E. B.} and S. O'Connell and Kukull, {W. A.}",
year = "1994",
month = "4",
day = "1",
language = "English",
volume = "44",
pages = "652--656",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Interrater agreement for diagnosis of Alzheimer's disease

T2 - The MIRAGE study

AU - Farrer, L. A.

AU - Cupples, L. A.

AU - Blackburn, S.

AU - Kiely, D. K.

AU - Auerbach, S.

AU - Growdon, J. H.

AU - Connor-Lacke, L.

AU - Karlinsky, H.

AU - Thibert, A.

AU - Burke, J. R.

AU - Utley, C.

AU - Chui, H.

AU - Ireland, A.

AU - Duara, R.

AU - Lopez Alberola, Roberto

AU - Larson, E. B.

AU - O'Connell, S.

AU - Kukull, W. A.

PY - 1994/4/1

Y1 - 1994/4/1

N2 - There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 ± 0.13) when the subjects were grouped as 'AD' (probable or possible) versus 'not AD,' but somewhat lower (0.52 ± 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.

AB - There are standardized criteria to assist in the diagnosis of Alzheimer's disease (AD), a disorder that lacks unique clinical, morphologic, or biochemical features. Diagnostic reliability of single groups of investigators using these criteria is moderate to substantial. In this study, seven clinicians at separate sites established a criteria-based diagnosis in 42 consecutive memory disorder patients participating in a national genetic epidemiologic study using a quantitative multiaxis AD rating scale (ADRS) that incorporates NINCDS/ADRDA criteria, reliability of information, and comorbidity. Reliability, measured by a generalized kappa statistic for more than two raters, was substantial (0.63 ± 0.13) when the subjects were grouped as 'AD' (probable or possible) versus 'not AD,' but somewhat lower (0.52 ± 0.10) when subjects were classified as probable AD, possible AD, or not AD. There was unanimous agreement for two-thirds of the subjects using a dichotomous classification scheme. These findings suggest that the ADRS is a useful diagnostic instrument for multicenter studies.

UR - http://www.scopus.com/inward/record.url?scp=0028316998&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028316998&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 652

EP - 656

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -