Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa

Samuel G. Jacobson, Katsuya Yagasaki, William J Feuer, Alejandro J. Román

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Heterozygotes of X-linked retinitis pigmentosa were studied with full field rod and cone electroretinography and light adapted kinetic perimetry. Twelve parameters from the electroretinograms (ERGs) and two parameters from the kinetic visual fields of both eyes of 22 heterozygotes were measured and statistical comparisons made with results from female control subjects. Rod and cone ERG amplitude parameters were significantly lower and cone timing delayed in the heterozygotes. Most of the ERG parameters that were abnormal in measured value also showed significantly greater interocular differences compared with controls. Kinetic visual fields with both V-4e and I-4e test targets were smaller in heterozygotes than in controls. Only with the I-4e target, however, were interocular differences significantly larger in the heterozygotes. For the I-4e target and many of the ERG parameters, using the interocular difference in conjunction with the measured parameter value from a single eye significantly increased the efficacy of discrimination between heterozygotes and controls; for some ERG parameters, the interocular difference alone provided the best separation of the two groups.

Original languageEnglish (US)
Pages (from-to)679-691
Number of pages13
JournalExperimental Eye Research
Volume48
Issue number5
DOIs
StatePublished - 1989

Fingerprint

Retinitis Pigmentosa
Heterozygote
Vertebrate Photoreceptor Cells
Visual Fields
Electroretinography
Visual Field Tests
Light

Keywords

  • cone
  • ERG
  • heterozygote
  • interocular difference, perimetry
  • retinitis pigmentosa
  • rod
  • visual field
  • X chromosome

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa. / Jacobson, Samuel G.; Yagasaki, Katsuya; Feuer, William J; Román, Alejandro J.

In: Experimental Eye Research, Vol. 48, No. 5, 1989, p. 679-691.

Research output: Contribution to journalArticle

Jacobson, Samuel G. ; Yagasaki, Katsuya ; Feuer, William J ; Román, Alejandro J. / Interocular asymmetry of visual function in heterozygotes of X-linked retinitis pigmentosa. In: Experimental Eye Research. 1989 ; Vol. 48, No. 5. pp. 679-691.
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