Abstract
A standardized grading scheme for the assessment of acute cellular rejection (ACR) in small-intestine transplantation was proposed in 2003 at the Eighth International Small Intestinal Transplantation Symposium. We have implemented the current grading scheme for ACR in small-bowel transplantation since October 2003. The pathologic diagnoses of those small-intestine biopsy samples, including ACR grade and other supplementary findings were evaluated. A total of 3484 small intestine biopsy samples from 155 patients were available for evaluation in this study. Frequency of grades 0, indeterminate, 1, 2, and 3 acute cellular rejection was 33.9%, 49.1%, 12.6%, 3.7%, and 0.8%, respectively. Duration of ACR episode strongly correlated with grade of ACR episode (P < .001). Other supplementary findings included acute vascular rejection component, 2.2%; increase in lymphoplasmacytic infiltrate in lamina propria, 15.7%; mucosal fibrosis, 0.4%; and regenerative changes, 0.3%. Our data substantiate that this grading system is reliable and useful for clinical decision making in bowel transplantation. We suggest that an assessment and quantification of supplementary findings be considered a component of the International Pathology Grading Scheme.
| Original language | English |
|---|---|
| Pages (from-to) | 47-53 |
| Number of pages | 7 |
| Journal | Transplantation Proceedings |
| Volume | 42 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2010 |
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ASJC Scopus subject areas
- Surgery
- Transplantation
Cite this
International Grading Scheme for Acute Cellular Rejection in Small-Bowel Transplantation : Single-Center Experience. / Ruiz, Phillip; Takahashi, H.; Delacruz, V.; Island, E.; Selvaggi, Gennaro; Nishida, Seigo; Moon, J.; Smith, Lesley J; Asaoka, T.; Levi, D.; Tekin, Akin; Tzakis, A. G.
In: Transplantation Proceedings, Vol. 42, No. 1, 01.01.2010, p. 47-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - International Grading Scheme for Acute Cellular Rejection in Small-Bowel Transplantation
T2 - Single-Center Experience
AU - Ruiz, Phillip
AU - Takahashi, H.
AU - Delacruz, V.
AU - Island, E.
AU - Selvaggi, Gennaro
AU - Nishida, Seigo
AU - Moon, J.
AU - Smith, Lesley J
AU - Asaoka, T.
AU - Levi, D.
AU - Tekin, Akin
AU - Tzakis, A. G.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - A standardized grading scheme for the assessment of acute cellular rejection (ACR) in small-intestine transplantation was proposed in 2003 at the Eighth International Small Intestinal Transplantation Symposium. We have implemented the current grading scheme for ACR in small-bowel transplantation since October 2003. The pathologic diagnoses of those small-intestine biopsy samples, including ACR grade and other supplementary findings were evaluated. A total of 3484 small intestine biopsy samples from 155 patients were available for evaluation in this study. Frequency of grades 0, indeterminate, 1, 2, and 3 acute cellular rejection was 33.9%, 49.1%, 12.6%, 3.7%, and 0.8%, respectively. Duration of ACR episode strongly correlated with grade of ACR episode (P < .001). Other supplementary findings included acute vascular rejection component, 2.2%; increase in lymphoplasmacytic infiltrate in lamina propria, 15.7%; mucosal fibrosis, 0.4%; and regenerative changes, 0.3%. Our data substantiate that this grading system is reliable and useful for clinical decision making in bowel transplantation. We suggest that an assessment and quantification of supplementary findings be considered a component of the International Pathology Grading Scheme.
AB - A standardized grading scheme for the assessment of acute cellular rejection (ACR) in small-intestine transplantation was proposed in 2003 at the Eighth International Small Intestinal Transplantation Symposium. We have implemented the current grading scheme for ACR in small-bowel transplantation since October 2003. The pathologic diagnoses of those small-intestine biopsy samples, including ACR grade and other supplementary findings were evaluated. A total of 3484 small intestine biopsy samples from 155 patients were available for evaluation in this study. Frequency of grades 0, indeterminate, 1, 2, and 3 acute cellular rejection was 33.9%, 49.1%, 12.6%, 3.7%, and 0.8%, respectively. Duration of ACR episode strongly correlated with grade of ACR episode (P < .001). Other supplementary findings included acute vascular rejection component, 2.2%; increase in lymphoplasmacytic infiltrate in lamina propria, 15.7%; mucosal fibrosis, 0.4%; and regenerative changes, 0.3%. Our data substantiate that this grading system is reliable and useful for clinical decision making in bowel transplantation. We suggest that an assessment and quantification of supplementary findings be considered a component of the International Pathology Grading Scheme.
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UR - http://www.scopus.com/inward/citedby.url?scp=76749162718&partnerID=8YFLogxK
U2 - 10.1016/j.transproceed.2009.12.026
DO - 10.1016/j.transproceed.2009.12.026
M3 - Article
C2 - 20172279
AN - SCOPUS:76749162718
VL - 42
SP - 47
EP - 53
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 1
ER -