Internal limiting membrane peeling

William E. Smiddy, William Feuer

Research output: Contribution to journalReview articlepeer-review


The substantial increase in macular hole surgery success rates has been attributed to various factors. Recently, the hypothesis that internal limiting membrane (ILM) peeling improves anatomic and visual success rates has been advanced. While numerous case reports have appeared addressing this issue, none have offered suitable controls to answer the question definitively. This review provides the evidence for and against ILM peeling and presents some data from one of these reports. Based on this evidence, peeling of the ILM, while not essential for anatomic or visual success, may represent a means of inducing a somewhat reproduceable, therapeutic degree of gliosis stimulus. Caution is advised, however, to avoid excessive, prolonged, unsuccessful attempts at ILM peeling, which may harm final visual outcome.

Original languageEnglish (US)
Pages (from-to)254-260
Number of pages7
JournalClinical and Surgical Ophthalmology
Issue number9
StatePublished - Sep 1 2004

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology


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