Internal carotid aplasia/hypoplasia and intracranial saccular aneurysms: Series of three new cases and systematic review of the literature

Walter E. Zink, Ricardo J. Komotar, Phillip M. Meyers

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background and Purpose. Abnormal arterial flow dynamics and intracranial collateral pathways can be seen in patients with congenital internal carotid artery (ICA) aplasia or hypoplasia. Here we seek to evaluate whether ICA aplasia/hypoplasia is associated with an increased prevalence of intracranial saccular aneurysm relative to carotid rete mirabile. Methods. We combined our experience of three cases with 148 previous publications to form a retrospective series including 132 cases of ICA aplasia, 33 cases of ICA hypoplasia, and 34 cases of carotid rete mirabile. Results. After excluding cases lacking angiograms, ICA aplasia/hypoplasia was more commonly associated with aneurysm (45/158, 27.8%) compared with rete mirabile (2/34, 5.9%). A significantly greater overall aneurysm prevalence was seen among ICA aplasia/hypoplasia patients age 30 years or older (38/101, 36.6%) than in younger individuals (7/48, 14.6%). Conclusions. Intracranial saccular aneurysm is more strongly associated with ICA aplasia/hypoplasia than rete mirabile. An increased aneurysm prevalence among older individuals with ICA aplasia/hypoplasia suggests an acquired etiology. Magnetic resonance angiography (MRA) is recommended in the initial evaluation of ICA aplasia/hypoplasia to evaluate for intracranial saccular aneurysm, particularly after the third decade of life.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalJournal of Neuroimaging
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2007
Externally publishedYes

Keywords

  • Aneurysm
  • Aplasia
  • Hypoplasia
  • Internal carotid artery
  • Rete mirabile

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'Internal carotid aplasia/hypoplasia and intracranial saccular aneurysms: Series of three new cases and systematic review of the literature'. Together they form a unique fingerprint.

  • Cite this