Interleukin-7, interleukin-8, soluble TNF receptor, and p53 protein levels are elevated in the serum of patients with Hodgkin's disease

L. Trumper, W. Jung, G. Dahl, V. Diehl, A. Gause, M. Pfreundschuh

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

In a search for specific serum markers with prognostic impact, we evaluated the clinical significance of IL-4, IL-7, and IL-8 as well as TNF receptor levels and soluble p53 in the serum of patients with untreated Hodgkin's lymphoma (HD). No elevations were observed for IL-4, while IL-7 and IL-8 were elevated in 15/52 (29%) and 21/78 (27%) patients, respectively. Soluble TNF receptors were detected in 16/29 patients (55%), and were significantly elevated in 6 (21%). P53 was detected in 21/33 (64%) patients. While IL-7 levels, detectable sTNF receptors, and p53 were not correlated with other obvious parameters, elevated IL-8 levels were associated with the presence of B symptoms (p < 0.002) and occurred more then in the nodular sclerosis form than in other histological subtypes (p < 0.02). Further investigations that correlate these serum parameters with the situation at the cellular level of an involved tissue will help to elucidate the enigmatic biology of HD.

Original languageEnglish (US)
Pages (from-to)93-96
Number of pages4
JournalAnnals of Oncology
Volume5
Issue numberSUPPL. 1
DOIs
StatePublished - 1994

Keywords

  • cytokines
  • Hodgkin's lymphoma
  • IL-4
  • IL-7
  • IL-8
  • p53
  • prognostic factors
  • TNF receptor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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