Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories

Mandip S. Dhamoon, Ying Kuen Cheung, Yeseon P. Moon, Clinton B. Wright, Ralph L Sacco, Mitchell S.V. Elkind

Research output: Contribution to journalArticle

Abstract

Background/Objectives Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. Design Prospective population based cohort study Setting The Northern Manhattan Study Participants (including the sample size) Race/ethnically diverse stroke-free individuals in northern Manhattan aged 40 years (n = 3298). Intervention None Measurements Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0–100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16–24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. Conclusion In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up.

Original languageEnglish (US)
Article numbere0214784
JournalPloS one
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2019

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1-Alkyl-2-acetylglycerophosphocholine Esterase
phospholipase A2
stroke
interleukin-6
lipoproteins
trajectories
Interleukin-6
Biomarkers
Stroke
Trajectories
myocardial infarction
biomarkers
risk factors
Myocardial Infarction
blood vessels
Functional assessment
demographic statistics
Demography
functional status
Serum

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. / Dhamoon, Mandip S.; Cheung, Ying Kuen; Moon, Yeseon P.; Wright, Clinton B.; Sacco, Ralph L; Elkind, Mitchell S.V.

In: PloS one, Vol. 14, No. 4, e0214784, 01.04.2019.

Research output: Contribution to journalArticle

Dhamoon, Mandip S. ; Cheung, Ying Kuen ; Moon, Yeseon P. ; Wright, Clinton B. ; Sacco, Ralph L ; Elkind, Mitchell S.V. / Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. In: PloS one. 2019 ; Vol. 14, No. 4.
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title = "Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories",
abstract = "Background/Objectives Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. Design Prospective population based cohort study Setting The Northern Manhattan Study Participants (including the sample size) Race/ethnically diverse stroke-free individuals in northern Manhattan aged 40 years (n = 3298). Intervention None Measurements Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0–100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results Mean age was 69 (SD 10) years, 35{\%} were male, 53{\%} Hispanic, 74{\%} hypertensive, and 16–24{\%} diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95{\%} CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95{\%} CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95{\%} CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. Conclusion In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up.",
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T1 - Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories

AU - Dhamoon, Mandip S.

AU - Cheung, Ying Kuen

AU - Moon, Yeseon P.

AU - Wright, Clinton B.

AU - Sacco, Ralph L

AU - Elkind, Mitchell S.V.

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N2 - Background/Objectives Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. Design Prospective population based cohort study Setting The Northern Manhattan Study Participants (including the sample size) Race/ethnically diverse stroke-free individuals in northern Manhattan aged 40 years (n = 3298). Intervention None Measurements Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0–100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16–24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. Conclusion In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up.

AB - Background/Objectives Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. Design Prospective population based cohort study Setting The Northern Manhattan Study Participants (including the sample size) Race/ethnically diverse stroke-free individuals in northern Manhattan aged 40 years (n = 3298). Intervention None Measurements Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0–100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. Results Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16–24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. Conclusion In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up.

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