Interleukin-6 and disease: Two case reports that point to the usefulness of measuring cytokine levels in clinical settings

Roberto Patarca, Mary Ann Fletcher

Research output: Contribution to journalArticle

1 Scopus citations


Chronic fatigue syndrome has been associated with patterns of cytokine imbalances whose relevance to disease status remains to be documented. We present here two case reports that illustrate the relevance of measuring interleukin-6 levels in biological fluids in two clinical entities: hypothermia and Sjogren's syndrome. Further studies of this nature in extended patient populations will allow to discern the relevant contribution among the pleiotropy of roles of each particular cytokine in different clinical settings. It becomes apparent from the cases presented that the clinical manifestation of the imbalance in the expression of a particular cytokine is contingent upon the compartment where it occurs and upon levels of other cytokines. Similar studies will allow to define signature cytokine imbalances for each disease condition and may also shed light on thus far uncharacterized etiological agents.

Original languageEnglish (US)
Pages (from-to)53-69
Number of pages17
JournalJournal Of Chronic Fatigue Syndrome
Issue number1
StatePublished - Mar 31 1998


ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this