Interleukin 3 is a growth factor for human follicular B cell lymphoma

Carol Clayberger, Sandra Luna-Fineman, Jeffrey E. Lee, Asha Pillai, Michael Campbell, Ronald Levy, Alan M. Krensky

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

More than one-half of adults with non-Hodgkin's B cell lymphomas present with low-grade follicular lymphomas. These tumor cells are found in dose association with follicular T lymphocytes and dendritic cells, suggesting that the surrounding ceils may play a role in the support of follicular tumors. Supernatants from activated human peripheral blood lymphocytes were found to promote the in vitro proliferation of follicular tumor cells. This effect was entirely due to interleukin 3 (IL-3), a factor generally thought to cause the growth and differentiation of immature hematopoietic cells. II.-3 receptors were detected on fresh isolates of all primary follicular cell tumors examined. These findings suggest that follicular cell tumors may be dependent in vivo on II.-3 and that therapies directed against IL-3, its receptor, or the T cells that produce it may be effective treatment for follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalJournal of Experimental Medicine
Volume175
Issue number2
DOIs
StatePublished - Feb 1 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Clayberger, C., Luna-Fineman, S., Lee, J. E., Pillai, A., Campbell, M., Levy, R., & Krensky, A. M. (1992). Interleukin 3 is a growth factor for human follicular B cell lymphoma. Journal of Experimental Medicine, 175(2), 371-376. https://doi.org/10.1084/jem.175.2.371