Abstract
Infection with human immunodeficiency virus (HIV)-1 induces a progressive deterioration of the immune system that ultimately leads to aquired immune deficiency syndrome (AIDS). Murine models indicate that the common γ-chain (γc)-sharing cytokine interleukin (IL)-21 and its receptor (IL-21R) play a crucial role in maintaining polyfunctional T cell responses during chronic viral infections. Therefore, we analyzed the ability of this cytokine to modulate the properties of human CD8 T cells in comparison with other γc-sharing cytokines (IL-2, IL-7, and IL-15). CD8 T cells from healthy volunteers were stimulated in vitro via T cell receptor signals to mimic the heightened status of immune activation of HIV-infected patients. The administration of IL-21 upregulated cytotoxic effector function and the expression of the costimulatory molecule CD28. Notably, this outcome was not accompanied by increased cellular proliferation or activation. Moreover, IL-21 promoted antiviral activity while not inducing HIV-1 replication in vitro. Thus, IL-21 may be a favorable molecule for immunotherapy and a suitable vaccine adjuvant in HIV-infected individuals.
Original language | English (US) |
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Pages (from-to) | 115-123 |
Number of pages | 9 |
Journal | Human Immunology |
Volume | 72 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2011 |
Keywords
- CD8 T lymphocytes
- Cytotoxicity
- HIV
- IL-21
- Immunotherapy
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy