Abstract
Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
| Original language | English |
|---|---|
| Pages (from-to) | 1575-1580 |
| Number of pages | 6 |
| Journal | Journal of Experimental Medicine |
| Volume | 161 |
| Issue number | 6 |
| State | Published - Jan 1 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Interleukin 2 upregulates expression of its receptor on a T cell clone. / Malek, Thomas; Ashwell, J. D.
In: Journal of Experimental Medicine, Vol. 161, No. 6, 01.01.1985, p. 1575-1580.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin 2 upregulates expression of its receptor on a T cell clone
AU - Malek, Thomas
AU - Ashwell, J. D.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
AB - Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021875442&partnerID=8YFLogxK
M3 - Article
VL - 161
SP - 1575
EP - 1580
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 6
ER -