Interleukin 2 upregulates expression of its receptor on a T cell clone

Thomas Malek, J. D. Ashwell

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.

Original languageEnglish
Pages (from-to)1575-1580
Number of pages6
JournalJournal of Experimental Medicine
Volume161
Issue number6
StatePublished - Jan 1 1985
Externally publishedYes

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Interleukin-2
Up-Regulation
Clone Cells
T-Lymphocytes
Messenger RNA
T Lymphocyte Differentiation Antigens
Thy-1 Antigens
Interleukin-2 Receptors
Histocompatibility Antigens Class II
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

Interleukin 2 upregulates expression of its receptor on a T cell clone. / Malek, Thomas; Ashwell, J. D.

In: Journal of Experimental Medicine, Vol. 161, No. 6, 01.01.1985, p. 1575-1580.

Research output: Contribution to journalArticle

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