Abstract
Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1575-1580 |
| Number of pages | 6 |
| Journal | Journal of Experimental Medicine |
| Volume | 161 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 1985 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Malek, T. R., & Ashwell, J. D. (1985). Interleukin 2 upregulates expression of its receptor on a t cell clone. Journal of Experimental Medicine, 161(6), 1575-1580. https://doi.org/10.1084/jem.161.6.1575