TY - JOUR
T1 - Interleukin 2 upregulates expression of its receptor on a t cell clone
AU - Malek, Thomas R.
AU - Ashwell, Jonathan D.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1985/6/1
Y1 - 1985/6/1
N2 - Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
AB - Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2-R molecules.
UR - http://www.scopus.com/inward/record.url?scp=0021875442&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021875442&partnerID=8YFLogxK
U2 - 10.1084/jem.161.6.1575
DO - 10.1084/jem.161.6.1575
M3 - Article
C2 - 3925066
AN - SCOPUS:0021875442
VL - 161
SP - 1575
EP - 1580
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 6
ER -