Interleukin-2 therapy for advanced chronic myeloid leukemia

M. Goodman, N. Spector, G. Rodrigues, P. A. Cassileth

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Chronic myeloid leukemia (CML) is usually treated with either alpha-interferon or hydrea. Median survival is 6 years. Eventually, in most CML patients, the disease evolves to blast phase with clinical and morphologic characteristics of an acute leukemia. This phase is commonly associated with systemic symptoms and the appearance of new cytogenetic abnormalities. Therapy for this phase is of limited value, resulting in a mean survival of 4 months. We describe four consecutive patients seen at our clinic with advanced stage CML (three blast, one accelerated phase) who were treated with interleukin-2 (Proleukin). The mean survival in these patients was 22 months (range 9-35 months) and two are still alive 25 and 35 months after the start of therapy. One patient had a complete cytogenetic response and another a partial response. Toxicity was minimal and no patient had to discontinue therapy because of it.

Original languageEnglish (US)
Pages (from-to)1682-1684
Number of pages3
JournalLeukemia
Volume12
Issue number11
DOIs
StatePublished - Jan 1 1998

Keywords

  • Blast crisis
  • Chronic myeloid leukemia
  • Interleukin-2 therapy

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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    Goodman, M., Spector, N., Rodrigues, G., & Cassileth, P. A. (1998). Interleukin-2 therapy for advanced chronic myeloid leukemia. Leukemia, 12(11), 1682-1684. https://doi.org/10.1038/sj.leu.2401200