Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

Thomas R. Malek, Iris Castro

Research output: Contribution to journalReview article

403 Scopus citations

Abstract

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo. IL-2R signaling influences two discrete aspects of immune responses by CD8+ T cells, terminal differentiation of effector cells in primary responses, and aspects of memory recall responses. IL-2 also delivers essential signals for thymic development of regulatory T (Treg) cells and later to promote their homeostasis and function. Each of these outcomes on T effector and Treg cells requires distinct amounts of IL-2R signaling, with low IL-2R signaling sufficient for many key aspects of Treg cells. Thus, tolerance is readily maintained and favored with limited IL-2.

Original languageEnglish (US)
Pages (from-to)153-165
Number of pages13
JournalImmunity
Volume33
Issue number2
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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