Abstract
Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95% CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.
| Original language | English |
|---|---|
| Pages (from-to) | 181-187 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 180 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1 2005 |
| Externally published | Yes |
Fingerprint
Keywords
- Atherosclerosis
- Cytokines
- Epidemiology
- Interleukin-2
- Intima-media thickness
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Interleukin-2 levels are associated with carotid artery intima-media thickness. / Elkind, Mitchell S V; Rundek, Tatjana; Sciacca, Robert R.; Ramas, Romel; Chen, Hong Jun; Boden-Albala, Bernadette; Rabbani, LeRoy; Sacco, Ralph L.
In: Atherosclerosis, Vol. 180, No. 1, 01.05.2005, p. 181-187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-2 levels are associated with carotid artery intima-media thickness
AU - Elkind, Mitchell S V
AU - Rundek, Tatjana
AU - Sciacca, Robert R.
AU - Ramas, Romel
AU - Chen, Hong Jun
AU - Boden-Albala, Bernadette
AU - Rabbani, LeRoy
AU - Sacco, Ralph L
PY - 2005/5/1
Y1 - 2005/5/1
N2 - Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95% CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.
AB - Objective: To show that serum interleukin levels are associated with carotid intima-media thickness (IMT). Background: Inflammation is hypothesized to play a central role in atherogenesis, and serum markers of inflammation are predictive of cardiovascular disease. Interleukin-2, a pro-inflammatory cytokine produced largely by naive CD4 T cells and Th1 (pro-inflammatory) T cells, has been found in a high proportion of carotid plaques. Methods: High-resolution ultrasound of the carotid arteries and serum cytokine levels were measured in stroke-free participants. The mean of the maximum IMT in bilateral bifurcation, common and internal carotid artery segments was measured. Serum levels of interleukin (IL)-1beta, IL-2, IL-6, C-reactive protein, tumor necrosis factor (TNF) alpha and TNF receptors were measured using enzyme-linked immunosorbent assay. Results: IL-2 levels were significantly correlated with IMT (r = 0.33, P < 0.0001), but other cytokines were not. Each unit increase in IL-2 was significantly associated with a mean increase in IMT of 0.18 mm (P = 0.0001). After adjusting for other atherosclerotic risk factors, the association was unchanged (mean increase in IMT per unit increase IL-2 = 0.18 mm, P < 0.0001). Each standard deviation increase in the level of IL-2 was associated with an increased risk (adjusted odds ratio 1.80, 95% CI 1.12-2.89) for an IMT ≥ 1.0 mm (75th percentile for IMT). Conclusion: Serum levels of IL-2, a pro-inflammatory cytokine, are associated with carotid artery IMT, a predictor of stroke and vascular disease. Serum inflammatory markers may provide a novel marker of atherosclerotic risk, and inflammation may provide a new therapeutic target for stroke prevention.
KW - Atherosclerosis
KW - Cytokines
KW - Epidemiology
KW - Interleukin-2
KW - Intima-media thickness
UR - http://www.scopus.com/inward/record.url?scp=17044366542&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17044366542&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2004.11.015
DO - 10.1016/j.atherosclerosis.2004.11.015
M3 - Article
C2 - 15823291
AN - SCOPUS:17044366542
VL - 180
SP - 181
EP - 187
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -