Interleukin 1 protects hair follicles from cytarabine (ARA-C)-induced toxicity in vivo and in vitro

J. J. Jimenez, M. E. Sawaya, A. A. Yunis

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


ImuVert, a biologic response modifier, and interleukin 1 (IL 1) have been shown to protect the young rat from alopecia induced by cytarabine (ARA-C). In the present study the inhibition by ARA-C of DNA synthesis in hair follicles (HFs) and the protective effect of ImuVert and IL 1 were investigated in vivo and in vitro. Both ImuVert and IL 1 were equally effective in protecting rats from ARA-C-induced alopecia. DNA synthesis in HFs isolated from ARA-C-treated animals was 10-20% of untreated controls. Follicles isolated from animals given either ImuVert or IL 1 before ARA-C exhibited normal DNA synthesis. In vitro, the incubation of normal rat HF with ARA-C resulted in 80% inhibition of [3H]-thymidine uptake. Preincubation of the follicles for 1 hr with IL 1 before the addition of ARA-C completely blocked the inhibition. Preincubation with imuVert, however, was less effective in blocking the inhibition from ARA-C.

Original languageEnglish (US)
Pages (from-to)911-913
Number of pages3
JournalFASEB Journal
Issue number3
StatePublished - Jan 1 1992


  • Alopecia
  • Chemotherapy
  • DNA synthesis
  • Hair follicles
  • I1 1
  • ImuVert

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology


Dive into the research topics of 'Interleukin 1 protects hair follicles from cytarabine (ARA-C)-induced toxicity in vivo and in vitro'. Together they form a unique fingerprint.

Cite this