Interleukin 1 protects from cytosine arabinoside-induced alopecia in the rat model

J. J. Jimenez, G. H.W. Wong, A. A. Yunis

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Protection from cytosine arabinoside-induced alopecia by ImuVert has recently been reported in a rat model. ImuVert, a biologic response modifier, is capable of activating mononuclear cells causing release of various cytokines. In the present study, using the young rat model, recombinant human IL 1β produced excellent protection from cytosine arabinoside-induced alopecia. Mouse recombinant tumor necrosis factor gave definite but modest protection whereas human tumor necrosis factor gave none. It is concluded that the protection from alopecia by ImuVert is mediated by cytokines, primarily IL 1.

Original languageEnglish (US)
Pages (from-to)2456-2458
Number of pages3
JournalFASEB Journal
Volume5
Issue number10
DOIs
StatePublished - Jan 1 1991

Keywords

  • Alopecia
  • Chemotherapy
  • Cytokines
  • Cytosine arabinoside
  • Interleukin 1

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Interleukin 1 protects from cytosine arabinoside-induced alopecia in the rat model'. Together they form a unique fingerprint.

Cite this