Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences

Jenny A. Udey, Bonnie B. Blomberg

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Evidence for gene conversion or unequal double crossover in the human λ light chain imunoglobulin locus is presented. The high level of J2C2-J3C3 Intron cross-hybridization, the identity of the Jλ2 and Jλ3 coding and intron sequences, the presence of multiple base differences between the Cλ2 and Cλ3 coding regions, and the presence of both the unconverted and converted all eles in the normal gene pool, suggest that a recombinational event has resulted in the conversion of the Jλ2 coding and intron sequences to those of Jλ3 and Its flanking sequences. Intergenic exchanges, such as the one described here, may provide a mechanism to maintain sequence homogeneity and functionality among the duplicated members of the human lambda gene family.

Original languageEnglish (US)
Pages (from-to)2959-2969
Number of pages11
JournalNucleic acids research
Volume16
Issue number7
DOIs
StatePublished - Apr 11 1988

ASJC Scopus subject areas

  • Genetics

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