Interferon-induced chronic active hepatitis?

Marcelo O. Silva, K. Rajender Reddy, Lennox J. Jeffers, Mary Hill, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.

Original languageEnglish (US)
Pages (from-to)840-842
Number of pages3
Issue number3
StatePublished - Sep 1991

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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