Abstract
A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.
| Original language | English |
|---|---|
| Pages (from-to) | 840-842 |
| Number of pages | 3 |
| Journal | Gastroenterology |
| Volume | 101 |
| Issue number | 3 |
| State | Published - Dec 1 1991 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Interferon-induced chronic active hepatitis? / Silva, Marcelo O.; Rajender Reddy, K.; Jeffers, Lennox J; Hill, Mary; Schiff, Eugene R.
In: Gastroenterology, Vol. 101, No. 3, 01.12.1991, p. 840-842.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interferon-induced chronic active hepatitis?
AU - Silva, Marcelo O.
AU - Rajender Reddy, K.
AU - Jeffers, Lennox J
AU - Hill, Mary
AU - Schiff, Eugene R
PY - 1991/12/1
Y1 - 1991/12/1
N2 - A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.
AB - A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025871262&partnerID=8YFLogxK
M3 - Article
C2 - 1860646
AN - SCOPUS:0025871262
VL - 101
SP - 840
EP - 842
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 3
ER -