Interferon-induced chronic active hepatitis?

Marcelo O. Silva, K. Rajender Reddy, Lennox J Jeffers, Mary Hill, Eugene R Schiff

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.

Original languageEnglish
Pages (from-to)840-842
Number of pages3
JournalGastroenterology
Volume101
Issue number3
StatePublished - Dec 1 1991

Fingerprint

Chronic Hepatitis
Interferon-alpha
Interferons
Antinuclear Antibodies
Chronic Hepatitis B
Brain Diseases
Virus Diseases
Prednisone
Jaundice
Hepatitis B
Ascites
Smooth Muscle
Immunoglobulin G

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Silva, M. O., Rajender Reddy, K., Jeffers, L. J., Hill, M., & Schiff, E. R. (1991). Interferon-induced chronic active hepatitis? Gastroenterology, 101(3), 840-842.

Interferon-induced chronic active hepatitis? / Silva, Marcelo O.; Rajender Reddy, K.; Jeffers, Lennox J; Hill, Mary; Schiff, Eugene R.

In: Gastroenterology, Vol. 101, No. 3, 01.12.1991, p. 840-842.

Research output: Contribution to journalArticle

Silva, MO, Rajender Reddy, K, Jeffers, LJ, Hill, M & Schiff, ER 1991, 'Interferon-induced chronic active hepatitis?', Gastroenterology, vol. 101, no. 3, pp. 840-842.
Silva MO, Rajender Reddy K, Jeffers LJ, Hill M, Schiff ER. Interferon-induced chronic active hepatitis? Gastroenterology. 1991 Dec 1;101(3):840-842.
Silva, Marcelo O. ; Rajender Reddy, K. ; Jeffers, Lennox J ; Hill, Mary ; Schiff, Eugene R. / Interferon-induced chronic active hepatitis?. In: Gastroenterology. 1991 ; Vol. 101, No. 3. pp. 840-842.
@article{10f9c8ba280e447a906e38def64ab397,
title = "Interferon-induced chronic active hepatitis?",
abstract = "A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these {"}autoimmune{"} features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.",
author = "Silva, {Marcelo O.} and {Rajender Reddy}, K. and Jeffers, {Lennox J} and Mary Hill and Schiff, {Eugene R}",
year = "1991",
month = "12",
day = "1",
language = "English",
volume = "101",
pages = "840--842",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Interferon-induced chronic active hepatitis?

AU - Silva, Marcelo O.

AU - Rajender Reddy, K.

AU - Jeffers, Lennox J

AU - Hill, Mary

AU - Schiff, Eugene R

PY - 1991/12/1

Y1 - 1991/12/1

N2 - A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.

AB - A 54-year-old man with chronic B hepatitis was treated with interferon alfa. Despite resolution of the hepatitis B viral infection, he experienced severe jaundice, ascites, and encephalopathy. Further work-up showed hyperglobulinemia, chiefly immunoglobulin G, and positive smooth muscle and antinuclear antibodies. Because of these "autoimmune" features, the patient was treated with prednisone. One month later, a significant clinical and biochemical improvement was observed. A possible autoimmune mechanism induced by interferon alfa is proposed as the cause for the perpetuation of the necroinflammatory activity.

UR - http://www.scopus.com/inward/record.url?scp=0025871262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025871262&partnerID=8YFLogxK

M3 - Article

C2 - 1860646

AN - SCOPUS:0025871262

VL - 101

SP - 840

EP - 842

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -