Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: A case report and review of the literature

Celeste Ann T. Bremer, Ashton Lastrapes, Arnold B. Alper, Raja Mudad

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Chronic myelogenous leukemia (CML), hepatitis C, and interferon alpha (IFNα) have all been associated with renal dysfunction. In this paper we present a patient with the diagnosis of nephrotic syndrome and a known history of hepatitis C who received IFNα therapy for newly diagnosed CML. The renal biopsy showed focal segmental glomerulosclerosis, which has only been previously reported in two cases of CML treated with IFNα. There have also been two cases of patients with hepatitis C associated with focal segmental glomerulosclerosis. Despite the underlying hepatitis C, this case represents renal abnormalities consistent with IFNα therapy for CML.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume26
Issue number3
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Keywords

  • Chronic myelogenous leukemia
  • Focal segmental glomerulosclerosis
  • Hepatitis C
  • Interferon alpha
  • Nephrotic syndrome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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