Interfacially photopolymerized hydrogels for local vascular drug delivery

J. L. West, Y. An, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

An interfacial photopolymerization method for the intravascular application of thin hydrogel barriers was developed. The hydrogels are well suited for localized intravascular delivery of hydrophilic macromolecules dissolved in the aqueous precursor solution and entrapped in the hydrogel after illumination. It was found that when platelet derived growth factor (PDGF) was locally delivered from the photopolymerized hydrogel after vascular injury, the thickness of the intimal layer of the arterial wall increased markedly. A protein can be delivered from a photopolymerized hydrogel while retaining its biological activity and the released protein can permeate through the vessel wall to act upon its target, medial smooth muscle cells.

Original languageEnglish
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Volume1
StatePublished - Dec 1 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    West, J. L., An, Y., & Hubbell, J. A. (1996). Interfacially photopolymerized hydrogels for local vascular drug delivery. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1). Soc for Biomaterials.