Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease

B. Horwitz, C. L. Grady, N. L. Schlageter, R. Duara, S. I. Rapoport

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

Patterns of cerebral metabolic correlations were compared between 21 Alzheimer's disease patients and 21 healthy age-matched controls in the resting state. Cerebral metabolic rates for glucose were determined by positron emission tomography using [18F]2-fluoro-2-deoxy-d-glucose. Partial correlation coefficients, controlling for whole brain glucose metabolism, were evaluated between pairs of regional glucose metabolic rates in 59 brain regions. Reliable correlation coefficients were obtained with the 'jackknife' and 'bootstrap' statistical procedures. Compared with healthy controls, the Alzheimer patients had significantly fewer reliable partial correlation coefficient between frontal and parietal lobe regions, and more reliable correlations between the cerebellum and temporal lobe. The number of reliable correlations between many bilaterally symmetric brain regions was reduced in the Alzheimer patients, as compared with controls. These results suggest that in the early stages of Alzheimer's disease there is a breakdown of the organized functional activity between the two cerebral hemispheres, and between parietal and frontal lobe structures.

Original languageEnglish (US)
Pages (from-to)294-306
Number of pages13
JournalBrain Research
Volume407
Issue number2
DOIs
StatePublished - Mar 31 1987

Keywords

  • Alzheimer's disease
  • Brain metabolism
  • Correlation matrix
  • Deoxyglucose
  • Positron emission tomography

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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