Abstract
Although the intercellular adhesion molecule-1 (ICAM-1) is recognized for its pivotal role in inflammation and immune responses, its role in developmental systems, such as the cyclic growth (anagen) and regression (catagen) of the hair follicle, remains to be explored. Here we demonstrate that ICAM-1 expression in murine skin is even more widespread and more developmentally regulated than was previously believed. In addition to endothelial cells, selected epidermal and follicular keratinocyte subpopulations, as well as interfollicular fibroblasts, express ICAM-1. Murine hair follicles express ICAM-1 only late during morphogenesis. Thereafter, morphologically identical follicles markedly differ in their ICAM-1 expression patterns, which become strikingly hair cycle-dependent in both intra- and extrafollicular skin compartments. Minimal ICAM-1 and leukocyte function-associated (LFA-1) protein and mRNA expression is observed during early anagen and maximal expression during late anagen and catagen. Keratinocytes of the distal outer root sheath, fibroblasts of the perifollicular connective tissue sheath, and perifollicular blood vessels exhibit maximal ICAM-1 immunoreactivity during catagen, which corresponds to changes of LFA-1 expression on perifollicular macrophages. Finally, ICAM-1- deficient mice display significant catagen acceleration compared to wild-type controls. Therefore, ICAM-1 upregulation is not limited to pathological situations but is also important for skin and hair follicle remodeling. Collectively, this suggests a new and apparently nonimmunological function for ICAM-1-related signaling in cutaneous biology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 557-568 |
| Number of pages | 12 |
| Journal | Journal of Histochemistry and Cytochemistry |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jan 1 2000 |
| Externally published | Yes |
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Keywords
- Adhesion molecules
- Catagen
- Connective tissue sheath
- Depilation
- Hair cycle
- ICAM-1-deficient mice
- LFA-1
- Mouse mutant
- Skin adhesion receptor
ASJC Scopus subject areas
- Anatomy
- Histology
Cite this
Intercellular adhesion molecule-1 and hair follicle regression. / Müller-Röver, Sven; Bulfone-Paus, Silvia; Handjiski, Bori; Welker, Pia; Sundberg, John P.; McKay, Ian A.; Botchkarev, Vladimir A.; Paus, Ralf.
In: Journal of Histochemistry and Cytochemistry, Vol. 48, No. 4, 01.01.2000, p. 557-568.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intercellular adhesion molecule-1 and hair follicle regression
AU - Müller-Röver, Sven
AU - Bulfone-Paus, Silvia
AU - Handjiski, Bori
AU - Welker, Pia
AU - Sundberg, John P.
AU - McKay, Ian A.
AU - Botchkarev, Vladimir A.
AU - Paus, Ralf
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Although the intercellular adhesion molecule-1 (ICAM-1) is recognized for its pivotal role in inflammation and immune responses, its role in developmental systems, such as the cyclic growth (anagen) and regression (catagen) of the hair follicle, remains to be explored. Here we demonstrate that ICAM-1 expression in murine skin is even more widespread and more developmentally regulated than was previously believed. In addition to endothelial cells, selected epidermal and follicular keratinocyte subpopulations, as well as interfollicular fibroblasts, express ICAM-1. Murine hair follicles express ICAM-1 only late during morphogenesis. Thereafter, morphologically identical follicles markedly differ in their ICAM-1 expression patterns, which become strikingly hair cycle-dependent in both intra- and extrafollicular skin compartments. Minimal ICAM-1 and leukocyte function-associated (LFA-1) protein and mRNA expression is observed during early anagen and maximal expression during late anagen and catagen. Keratinocytes of the distal outer root sheath, fibroblasts of the perifollicular connective tissue sheath, and perifollicular blood vessels exhibit maximal ICAM-1 immunoreactivity during catagen, which corresponds to changes of LFA-1 expression on perifollicular macrophages. Finally, ICAM-1- deficient mice display significant catagen acceleration compared to wild-type controls. Therefore, ICAM-1 upregulation is not limited to pathological situations but is also important for skin and hair follicle remodeling. Collectively, this suggests a new and apparently nonimmunological function for ICAM-1-related signaling in cutaneous biology.
AB - Although the intercellular adhesion molecule-1 (ICAM-1) is recognized for its pivotal role in inflammation and immune responses, its role in developmental systems, such as the cyclic growth (anagen) and regression (catagen) of the hair follicle, remains to be explored. Here we demonstrate that ICAM-1 expression in murine skin is even more widespread and more developmentally regulated than was previously believed. In addition to endothelial cells, selected epidermal and follicular keratinocyte subpopulations, as well as interfollicular fibroblasts, express ICAM-1. Murine hair follicles express ICAM-1 only late during morphogenesis. Thereafter, morphologically identical follicles markedly differ in their ICAM-1 expression patterns, which become strikingly hair cycle-dependent in both intra- and extrafollicular skin compartments. Minimal ICAM-1 and leukocyte function-associated (LFA-1) protein and mRNA expression is observed during early anagen and maximal expression during late anagen and catagen. Keratinocytes of the distal outer root sheath, fibroblasts of the perifollicular connective tissue sheath, and perifollicular blood vessels exhibit maximal ICAM-1 immunoreactivity during catagen, which corresponds to changes of LFA-1 expression on perifollicular macrophages. Finally, ICAM-1- deficient mice display significant catagen acceleration compared to wild-type controls. Therefore, ICAM-1 upregulation is not limited to pathological situations but is also important for skin and hair follicle remodeling. Collectively, this suggests a new and apparently nonimmunological function for ICAM-1-related signaling in cutaneous biology.
KW - Adhesion molecules
KW - Catagen
KW - Connective tissue sheath
KW - Depilation
KW - Hair cycle
KW - ICAM-1-deficient mice
KW - LFA-1
KW - Mouse mutant
KW - Skin adhesion receptor
UR - http://www.scopus.com/inward/record.url?scp=2542508715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542508715&partnerID=8YFLogxK
U2 - 10.1177/002215540004800413
DO - 10.1177/002215540004800413
M3 - Article
C2 - 10727297
AN - SCOPUS:2542508715
VL - 48
SP - 557
EP - 568
JO - Journal of Histochemistry and Cytochemistry
JF - Journal of Histochemistry and Cytochemistry
SN - 0022-1554
IS - 4
ER -