Interactions of neurotensin with dopamine-containing neurons in the central nervous system

Gregory N. Ervin, Charles B. Nemeroff

Research output: Contribution to journalArticle

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Abstract

Ervin, Gregory N. and Charles B. Nemeroff: Interactions of Neurotensin with Dopamine Containing Neurons in the Central Nervous System. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1988, 12 (Suppl): S53-S69. 1. 1. Neurotensin (NT) is a tridecapeptide that fulfills many of the requisite criteria for neurotransmitter status in the mammalian central nervous system. 2. 2. Neuroanatomical studies have revealed that DA and NT neurons are proximal in several limbic areas and that NT receptors are present on both DA perikaya and certain DA nerve terminals. 3. 3. When injected intraventricularly or directly into the nucleus accumbens (ACC), NT produces effects similar to antlpsychotic drugs e.g. blockade of the hyperactivity produced by d-amphetamine or cocaine. 4. 4. Chronic administration of antipsychotic drugs such as haloperidol produces increases in NT concentration in the ACC and caudate nucleus. Atypical antipsychotic drugs produce increases in NT concentration only in the ACC. 5. 5. In certain drug-free schizophrenic patients, the concentration of NT in cerebrospinal fluid is reduced. 6. 6. It appears that NT may modulate the activity of DA neurons in the mesolimbicocortical DA system.

Original languageEnglish (US)
Pages (from-to)S53-S69
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume12
Issue numberSUPPL. 1
DOIs
StatePublished - 1988

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Keywords

  • antipsychotic drugs
  • central nervous system
  • dopamine systems
  • neurotensin
  • schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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