Interactions of cytokine gene polymorphisms in prostate cancer risk

Jovanny Zabaleta, Hui Yi Lin, Rosa A. Sierra, M. Craig Hall, Peter E. Clark, Oliver A. Sartor, Jennifer Hu, Augusto C. Ochoa

Research output: Contribution to journalArticle

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Abstract

Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and possibly increased CaP risk. However, the effects of cytokine SNPs on CaP susceptibility have not been consistent. Using the genomic DNA collected in a CaP case-control study (557 cases and 547 controls), we pilot tested the interactions of nine functionally characterized SNPs of three cytokine genes in CaP risk using the multivariate adaptive regression splines (MARS)-logit models. African-Americans with the IL10-819TT genotype had a lower CaP risk [odds ratio (OR) = 0.27, 95% confidence interval (CI) = 0.07-1.01], but subjects with the genotype combination of IL1B-511CT/TT and IL10-592CC had a higher CaP risk (OR = 2.56, 95% CI = 1.09-6.02). In Caucasians, higher CaP risk was associated with the IL10-1082AG/GG genotype (OR = 3.62, 95% CI = 1.42-9.28), the genotype combination of IL10-1082AA plus IL1B-31TT/TC (OR = 2.92, 95% CI = 1.13-7.55) and the genotype combination of TNF-238GG plus IL10-592AA (OR = 2.14, 95% CI = 1.05-4.38). Our results highlight the importance of cytokine SNPs and their interactions in CaP risk.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalCarcinogenesis
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2008

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Prostatic Neoplasms
Odds Ratio
Cytokines
Interleukin-10
Genotype
Single Nucleotide Polymorphism
Confidence Intervals
Genes
Inflammation
African Americans
Case-Control Studies
Cause of Death
Logistic Models
DNA
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Zabaleta, J., Lin, H. Y., Sierra, R. A., Hall, M. C., Clark, P. E., Sartor, O. A., ... Ochoa, A. C. (2008). Interactions of cytokine gene polymorphisms in prostate cancer risk. Carcinogenesis, 29(3), 573-578. https://doi.org/10.1093/carcin/bgm277

Interactions of cytokine gene polymorphisms in prostate cancer risk. / Zabaleta, Jovanny; Lin, Hui Yi; Sierra, Rosa A.; Hall, M. Craig; Clark, Peter E.; Sartor, Oliver A.; Hu, Jennifer; Ochoa, Augusto C.

In: Carcinogenesis, Vol. 29, No. 3, 01.03.2008, p. 573-578.

Research output: Contribution to journalArticle

Zabaleta, J, Lin, HY, Sierra, RA, Hall, MC, Clark, PE, Sartor, OA, Hu, J & Ochoa, AC 2008, 'Interactions of cytokine gene polymorphisms in prostate cancer risk', Carcinogenesis, vol. 29, no. 3, pp. 573-578. https://doi.org/10.1093/carcin/bgm277
Zabaleta J, Lin HY, Sierra RA, Hall MC, Clark PE, Sartor OA et al. Interactions of cytokine gene polymorphisms in prostate cancer risk. Carcinogenesis. 2008 Mar 1;29(3):573-578. https://doi.org/10.1093/carcin/bgm277
Zabaleta, Jovanny ; Lin, Hui Yi ; Sierra, Rosa A. ; Hall, M. Craig ; Clark, Peter E. ; Sartor, Oliver A. ; Hu, Jennifer ; Ochoa, Augusto C. / Interactions of cytokine gene polymorphisms in prostate cancer risk. In: Carcinogenesis. 2008 ; Vol. 29, No. 3. pp. 573-578.
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