Interactions between pineal, hypothalamus and pituitary involving melatonin, MSH release-inhibiting factor and MSH

Abba J. Kastin, Sharon Viosca, R. M.G. Nair, Andrew V. Schally, M. Clinton Miller

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

Increased melanocyte-lightening activity was found in the plasma of hypophysectomized rats as assayed by direct application to the pituitaries of frogs which had been previously darkened by removal of the hypothalamus. A decrease in this activity by destruction of the hypothalamus of the hypophysectomized rat suggested that MSH release-inhibiting factor (MIF) was involved. Pinealectomy of the hypophysectomized rat or extraction of the plasma with chloroform also decreased the plasma melanocyte-lightening activity, indicating the contribution of melatonin to the lightening effect. The presence of increased amounts of both Pro-Leu-Gly-NH2 (PLG), an MIF, and melatonin in the plasma of hypophysectomized rats, as compared with intact controls, was supported by the use of thin-layer chromatography. In addition, a potentiating action of PLG upon the skin lightening activity of melatonin was observed. These experiments suggest new dimensions to the pineal-hypothalamic-pituitary axis.

Original languageEnglish (US)
Pages (from-to)1323-1328
Number of pages6
JournalEndocrinology
Volume91
Issue number5
DOIs
StatePublished - Nov 1972
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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