TY - JOUR
T1 - Interaction of stress, corticotropin-releasing factor, arginine vasopressin and behaviour
AU - Beurel, Eléonore
AU - Nemeroff, Charles B.
N1 - Funding Information:
The authors apologize to the many investigators whose work could not be cited due to the limited number of references permitted. Research in the authors laboratories were supported by NIH grants MH090236 and MH094759.
Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2014.
PY - 2014
Y1 - 2014
N2 - Stress mediates the activation of a variety of systems ranging from inflammatory to behavioral responses. In this review we focus on two neuropeptide systems, corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and their roles in regulating stress responses. Both peptides have been demonstrated to be involved in anxiogenic and depressive effects, actions mediated in part through their regulation of the hypothalamic-pituitary-adrenal axis and the release of adrenocorticotropic hormone. Because of the depressive effects of CRF and AVP, drugs modifying the stress-associated detrimental actions of CRF and AVP are under development, particularly drugs antagonizing CRF and AVP receptors for therapy in depression.
AB - Stress mediates the activation of a variety of systems ranging from inflammatory to behavioral responses. In this review we focus on two neuropeptide systems, corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and their roles in regulating stress responses. Both peptides have been demonstrated to be involved in anxiogenic and depressive effects, actions mediated in part through their regulation of the hypothalamic-pituitary-adrenal axis and the release of adrenocorticotropic hormone. Because of the depressive effects of CRF and AVP, drugs modifying the stress-associated detrimental actions of CRF and AVP are under development, particularly drugs antagonizing CRF and AVP receptors for therapy in depression.
KW - Arginine vasopressin
KW - Behaviour
KW - Corticotropin-releasing factor
KW - Stress
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U2 - 10.1007/7854_2014_306
DO - 10.1007/7854_2014_306
M3 - Article
AN - SCOPUS:84922056319
VL - 18
SP - 67
EP - 80
JO - Current Topics in Behavioral Neurosciences
JF - Current Topics in Behavioral Neurosciences
SN - 1866-3370
ER -