Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors: effects on colonic temperature in mice

George A. Mason, Daniel E. Hernandez, Charles B. Nemeroff, Jimmie W. Adcock, Ossie L. Hatley, Arthur J. Prange

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Neurotensin (NT) administered intracisternally (i.c.) to adult mice produced a marked hypothermia while prostaglandin E2, administered by the same route, produced hyperthermia. When administered concurrently the effects of the two substances were neutralized. The prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, were injected subcutaneously 30 min prior to i.c. administered NT and/or thyrotropin-releasing hormone (TRH). Both inhibitors failed to potentiate the hypothermia induced by NT or alter its antagonism by TRH in mice kept at 26°C. When mice were kept at 6°C, pretreatment with indomethacin, but not acetylsalicylic acid, potentiated NT-induced hypothermia and prevented its antagonism by TRH. Because indomethacin inhibits synthesis of prostaglandins within the central nervous system (CNS) as well as in peripheral organs while acetylsalicylic acid acts only in the periphery, it appears that NT-induced hypothermia in a cold environment is enhanced by a reduction of prostaglandins in the CNS.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalRegulatory Peptides
Volume4
Issue number5
DOIs
StatePublished - Oct 1982
Externally publishedYes

Keywords

  • acetylsalicylic acid
  • chlorpromazine
  • colonic temperature
  • indomethacin
  • thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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