TY - JOUR
T1 - Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors
T2 - effects on colonic temperature in mice
AU - Mason, George A.
AU - Hernandez, Daniel E.
AU - Nemeroff, Charles B.
AU - Adcock, Jimmie W.
AU - Hatley, Ossie L.
AU - Prange, Arthur J.
PY - 1982/10
Y1 - 1982/10
N2 - Neurotensin (NT) administered intracisternally (i.c.) to adult mice produced a marked hypothermia while prostaglandin E2, administered by the same route, produced hyperthermia. When administered concurrently the effects of the two substances were neutralized. The prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, were injected subcutaneously 30 min prior to i.c. administered NT and/or thyrotropin-releasing hormone (TRH). Both inhibitors failed to potentiate the hypothermia induced by NT or alter its antagonism by TRH in mice kept at 26°C. When mice were kept at 6°C, pretreatment with indomethacin, but not acetylsalicylic acid, potentiated NT-induced hypothermia and prevented its antagonism by TRH. Because indomethacin inhibits synthesis of prostaglandins within the central nervous system (CNS) as well as in peripheral organs while acetylsalicylic acid acts only in the periphery, it appears that NT-induced hypothermia in a cold environment is enhanced by a reduction of prostaglandins in the CNS.
AB - Neurotensin (NT) administered intracisternally (i.c.) to adult mice produced a marked hypothermia while prostaglandin E2, administered by the same route, produced hyperthermia. When administered concurrently the effects of the two substances were neutralized. The prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, were injected subcutaneously 30 min prior to i.c. administered NT and/or thyrotropin-releasing hormone (TRH). Both inhibitors failed to potentiate the hypothermia induced by NT or alter its antagonism by TRH in mice kept at 26°C. When mice were kept at 6°C, pretreatment with indomethacin, but not acetylsalicylic acid, potentiated NT-induced hypothermia and prevented its antagonism by TRH. Because indomethacin inhibits synthesis of prostaglandins within the central nervous system (CNS) as well as in peripheral organs while acetylsalicylic acid acts only in the periphery, it appears that NT-induced hypothermia in a cold environment is enhanced by a reduction of prostaglandins in the CNS.
KW - acetylsalicylic acid
KW - chlorpromazine
KW - colonic temperature
KW - indomethacin
KW - thyrotropin-releasing hormone
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U2 - 10.1016/0167-0115(82)90121-5
DO - 10.1016/0167-0115(82)90121-5
M3 - Article
C2 - 6960393
AN - SCOPUS:0020360875
VL - 4
SP - 285
EP - 292
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 5
ER -