Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors: effects on colonic temperature in mice

George A. Mason, Daniel E. Hernandez, Charles Nemeroff, Jimmie W. Adcock, Ossie L. Hatley, Arthur J. Prange

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Neurotensin (NT) administered intracisternally (i.c.) to adult mice produced a marked hypothermia while prostaglandin E2, administered by the same route, produced hyperthermia. When administered concurrently the effects of the two substances were neutralized. The prostaglandin synthesis inhibitors, indomethacin and acetylsalicylic acid, were injected subcutaneously 30 min prior to i.c. administered NT and/or thyrotropin-releasing hormone (TRH). Both inhibitors failed to potentiate the hypothermia induced by NT or alter its antagonism by TRH in mice kept at 26°C. When mice were kept at 6°C, pretreatment with indomethacin, but not acetylsalicylic acid, potentiated NT-induced hypothermia and prevented its antagonism by TRH. Because indomethacin inhibits synthesis of prostaglandins within the central nervous system (CNS) as well as in peripheral organs while acetylsalicylic acid acts only in the periphery, it appears that NT-induced hypothermia in a cold environment is enhanced by a reduction of prostaglandins in the CNS.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalRegulatory Peptides
Volume4
Issue number5
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

Fingerprint

Prostaglandin Antagonists
Neurotensin
Hypothermia
Dinoprostone
Prostaglandins
Induced Hypothermia
Thyrotropin-Releasing Hormone
Temperature
Indomethacin
Aspirin
Neurology
Central Nervous System
Fever

Keywords

  • acetylsalicylic acid
  • chlorpromazine
  • colonic temperature
  • indomethacin
  • thyrotropin-releasing hormone

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this

Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors : effects on colonic temperature in mice. / Mason, George A.; Hernandez, Daniel E.; Nemeroff, Charles; Adcock, Jimmie W.; Hatley, Ossie L.; Prange, Arthur J.

In: Regulatory Peptides, Vol. 4, No. 5, 01.01.1982, p. 285-292.

Research output: Contribution to journal › Article

Mason, GA, Hernandez, DE, Nemeroff, C, Adcock, JW, Hatley, OL & Prange, AJ 1982, 'Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors: effects on colonic temperature in mice', Regulatory Peptides, vol. 4, no. 5, pp. 285-292. https://doi.org/10.1016/0167-0115(82)90121-5
Mason GA, Hernandez DE, Nemeroff C, Adcock JW, Hatley OL, Prange AJ. Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors: effects on colonic temperature in mice. Regulatory Peptides. 1982 Jan 1;4(5):285-292. https://doi.org/10.1016/0167-0115(82)90121-5
Mason, George A. ; Hernandez, Daniel E. ; Nemeroff, Charles ; Adcock, Jimmie W. ; Hatley, Ossie L. ; Prange, Arthur J. / Interaction of neurotensin with prostaglandin E2 and prostaglandin synthesis inhibitors : effects on colonic temperature in mice. In: Regulatory Peptides. 1982 ; Vol. 4, No. 5. pp. 285-292.
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