Interaction and domain networks of yeast

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Data of currently available protein-protein interaction sets and protein domain sets of yeast are used to set up protein and domain interaction and domain sequence networks. All of them are far from being random or regular networks. In fact, they turn out to be sparse and locally well clustered indicating so-called scale-free and partially small-world topology. These subtle topologies display considerable indirect properties which are measured with a newly introduced transitivity coefficient. Fairly small sets of highly connected proteins and domains shape the topologies of the underlying networks, emphasizing a kind of backbone the nets are based on. The biological nature of these particular nodes is further investigated. Since highly connected proteins and domains accumulated a significant higher number of links by their important involvement in certain cellular aspects, their mutational effect on the cell is considered by a perturbation analysis. In comparison to domains of yeast, what factors force domains to accumulate links to other domains in protein sequences of higher eukaryotes are investigated.

Original languageEnglish (US)
Pages (from-to)1715-1723
Number of pages9
JournalProteomics
Volume2
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

Keywords

  • Domain fusion events
  • Lethality and viability
  • Scale-free and small-world topology
  • Transitivity of interactions
  • Yeast networks

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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