Inter-session repeatability of retinal layer thickness in optical coherence tomography

Delia Cabrera DeBuc, Jing Tian, Nathan Bates, Gabor Mark Somfai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Reliable retinal layer thickness measurements using optical coherence tomography (OCT) are important to track the subtle retinal changes in longitudinal studies. A total of 10 eyes (5 healthy subjects, 40±13 years old) were enrolled to study the inter-session repeatability and identify the pitfalls affecting the reliabilities. Each eye was scanned using spectral domain OCT (Spectralis SDOCT, Heidelberg Engineering) for 3 sessions with 30 seconds rest in between. The first and second sessions were scanned independently and the third one was scanned with the first one as the baseline visit. Each session consisted of a confocal scanning laser ophthalmoscopy (cSLO) image and 61 B-scans of 496×768 pixels. The first, second and third sessions were named as baseline, unregistered and registered sessions; respectively. Seven retinal layers labeled as RNFL, GCL+IPL, INL, OPL, ONL, IS and OS were segmented using a custom software (OCTRIMA3D) and measured in the ETDRS grid. Inter-session standard deviation (σ), coefficient of repeatability (CR) and coefficient of variations (COV) were calculated to quantify the repeatability. Paired t-test of COVs was used to compare the repeatability and the level of significance was set at 5%. We obtained that values of the CR <5 μm and COV of 5%, were revealed only in the outer layers. The values of COV were not significantly different (p<0.05) in the unregistered scanning session. Our results show that the rotations in the unregistered scanning sessions do not cause significant change in repeatability.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2017
Subtitle of host publicationBiomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
Volume10137
ISBN (Electronic)9781510607194
DOIs
StatePublished - 2017
EventMedical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging - Orlando, United States
Duration: Feb 12 2017Feb 14 2017

Other

OtherMedical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CityOrlando
Period2/12/172/14/17

Fingerprint

Optical tomography
Optical Coherence Tomography
tomography
Scanning
Ophthalmoscopy
coefficients
Longitudinal Studies
Healthy Volunteers
Lasers
Thickness measurement
Software
scanning
Pixels
optical measurement
standard deviation
pixels
grids
engineering
computer programs
causes

Keywords

  • Optical coherence tomography
  • Registration
  • Repeatability
  • Retinal layer thickness
  • Segmentation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Cabrera DeBuc, D., Tian, J., Bates, N., & Somfai, G. M. (2017). Inter-session repeatability of retinal layer thickness in optical coherence tomography. In Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 10137). [101371J] SPIE. https://doi.org/10.1117/12.2254640

Inter-session repeatability of retinal layer thickness in optical coherence tomography. / Cabrera DeBuc, Delia; Tian, Jing; Bates, Nathan; Somfai, Gabor Mark.

Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 10137 SPIE, 2017. 101371J.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cabrera DeBuc, D, Tian, J, Bates, N & Somfai, GM 2017, Inter-session repeatability of retinal layer thickness in optical coherence tomography. in Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 10137, 101371J, SPIE, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, Orlando, United States, 2/12/17. https://doi.org/10.1117/12.2254640
Cabrera DeBuc D, Tian J, Bates N, Somfai GM. Inter-session repeatability of retinal layer thickness in optical coherence tomography. In Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 10137. SPIE. 2017. 101371J https://doi.org/10.1117/12.2254640
Cabrera DeBuc, Delia ; Tian, Jing ; Bates, Nathan ; Somfai, Gabor Mark. / Inter-session repeatability of retinal layer thickness in optical coherence tomography. Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 10137 SPIE, 2017.
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