Integrative treatment for chronic wounds

Evan Darwin, Alexandra R. Vaughn, Hadar Lev-Tov

Research output: Chapter in Book/Report/Conference proceedingChapter


Normal wound healing is a carefully orchestrated biological process in which a series of key phases occur, resulting in epidermal closure and scar formation. Immediately following an injury, the body utilizes several mechanisms to ensure hemostasis. Venous leg ulcers (VLUs) are wounds that form on the lower legs in patients with chronic venous insufficiency (CVI). Diabetic foot ulcers (DFUs) are primarily caused by diabetes induced peripheral neuropathy, leading to skin breakdown due to excess pressure on the foot and gait abnormalities. Pressure ulcers are a common occurrence in the acute care setting. Hidradenitis suppurativa is a chronic inflammatory skin disease with unclear etiology, characterized by nodules, abscesses, and scarring of apocrine gland-bearing skin areas. Chronic wounds significantly impact the social and emotional wellness of patients. Skin grafts have been used for millennia in the treatment of chronic wounds. The mainstay of treatment for VLUs is local wound care and compression therapy.

Original languageEnglish (US)
Title of host publicationAdvances in Integrative Dermatology
Number of pages26
ISBN (Electronic)9781119476009
ISBN (Print)9781119476047
StatePublished - Jan 25 2019


  • Chronic venous insufficiency
  • Chronic wounds
  • Compression therapy
  • Diabetic foot ulcers
  • Hemostasis
  • Hidradenitis suppurativa
  • Pressure ulcers
  • Skin grafts
  • Venous leg ulcers

ASJC Scopus subject areas

  • Medicine(all)


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