Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications

Dominique A. Rothenfluh, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.

Original languageEnglish
Pages (from-to)446-451
Number of pages6
JournalIntegrative Biology
Volume1
Issue number7
DOIs
StatePublished - Dec 1 2009
Externally publishedYes

Fingerprint

Drug and Narcotic Control
Drug delivery
Nanoparticles
Drug Carriers
Drug Design
Biocompatible Materials
Biomolecules
Biological systems
Technology
Drug Liberation

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Medicine(all)

Cite this

Integration column : Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications. / Rothenfluh, Dominique A.; Hubbell, Jeffrey A.

In: Integrative Biology, Vol. 1, No. 7, 01.12.2009, p. 446-451.

Research output: Contribution to journalArticle

@article{74c9e48d2157400bb0e29fb7ace04b27,
title = "Integration column: Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications",
abstract = "Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.",
author = "Rothenfluh, {Dominique A.} and Hubbell, {Jeffrey A.}",
year = "2009",
month = "12",
day = "1",
doi = "10.1039/b907627c",
language = "English",
volume = "1",
pages = "446--451",
journal = "Integrative Biology (United Kingdom)",
issn = "1757-9694",
publisher = "Royal Society of Chemistry",
number = "7",

}

TY - JOUR

T1 - Integration column

T2 - Biofunctional polymeric nanoparticles for spatio-temporal control of drug delivery and biomedical applications

AU - Rothenfluh, Dominique A.

AU - Hubbell, Jeffrey A.

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.

AB - Polymeric nanoparticle technology has evolved from drug carrier design to advanced multifunctional macromolecular structures. They enable drug delivery and release of a bioactive under spatio-temporal control rather than just passive release by a long-circulating carrier. As such, the carrier is enabling the biomolecule or the bioactive to carry out its designed biological function. Due to their small size nanoparticles may also induce perturbations of biological systems different from any other biomaterials, therefore opening up new biomedical applications as well as raising concerns about adverse effects.

UR - http://www.scopus.com/inward/record.url?scp=77949331525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949331525&partnerID=8YFLogxK

U2 - 10.1039/b907627c

DO - 10.1039/b907627c

M3 - Article

C2 - 20023754

AN - SCOPUS:77949331525

VL - 1

SP - 446

EP - 451

JO - Integrative Biology (United Kingdom)

JF - Integrative Biology (United Kingdom)

SN - 1757-9694

IS - 7

ER -