Integrating biosensors and drug delivery: A step closer toward scalable responsive drug-delivery systems

Han Kuan Anthony Tsai, Elizabeth A. Moschou, Sylvia Daunert, Marc Madou, Lawrence Kulinsky

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The integration of a biosensor for glucose employing glucose oxidase immobilized on a hydrogel contained with microfabricated vials of a device, was studied. The drug delivery system can be manufactured in two parts, universal substrate and individually controllers drug release valves. The molded PDMS reservoir with dimensions of 17.8mm × 12.7mm × 0.5mm was filled with insulin and sealed to silicon substrate. The substrate for the drug-delivery device was produced from a single-crystal silicon wafer covered with a 200nm thick silicon dioxide through plasma enhanced chemical vapor deposition (PECVD) process. The study demonstrated the possibility of both independent sensing and drug delivery from the microwaves. The experiment resulted the increase in sensitivity of biosensor's to glucose with a dynamic linear response, suitable for use in hypoglycemic as well as hyperglycemic conditions.

Original languageEnglish
Pages (from-to)656-660
Number of pages5
JournalAdvanced Materials
Volume21
Issue number6
DOIs
StatePublished - Feb 9 2009
Externally publishedYes

Fingerprint

Drug delivery
Biosensors
Glucose
Substrates
Glucose Oxidase
Glucose oxidase
Hydrogel
Insulin
Silicon
Plasma enhanced chemical vapor deposition
Silicon wafers
Hypoglycemic Agents
Hydrogels
Silicon Dioxide
Silica
Microwaves
Single crystals
Controllers
Pharmaceutical Preparations
Drug Delivery Systems

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Integrating biosensors and drug delivery : A step closer toward scalable responsive drug-delivery systems. / Tsai, Han Kuan Anthony; Moschou, Elizabeth A.; Daunert, Sylvia; Madou, Marc; Kulinsky, Lawrence.

In: Advanced Materials, Vol. 21, No. 6, 09.02.2009, p. 656-660.

Research output: Contribution to journalArticle

Tsai, Han Kuan Anthony ; Moschou, Elizabeth A. ; Daunert, Sylvia ; Madou, Marc ; Kulinsky, Lawrence. / Integrating biosensors and drug delivery : A step closer toward scalable responsive drug-delivery systems. In: Advanced Materials. 2009 ; Vol. 21, No. 6. pp. 656-660.
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