Abstract
Neuropeptides produced, stored and secreted by the unusually dense sensory and autonomic innervation of hair follicles (HFs) can induce hair growth (anagen) and may be involved in hair growth control. To test the role of follicle innervation of HF cycling in vivo, we generated innervation-deficient HFs by unilateral surgical denervation of a defined region of back skin in C57BL/6 mice and assessed its effect on spontaneous and induced anagen development. Successful denervation was demonstrated by the absence of PGP 9.5+ or tyrosine hydroxylase+ nerves and nerve-associated neuropeptides (substance P, CGRP). By quantitative histomorphometry, no significant difference in spontaneous or cyclosporin A-induced anagen development could be detected between sham-operated control skin and denervated skin. Only after hair growth induction by depilation, a discrete, marginally significant retardation of anagen development was apparent in denervated HFs. Thus, even though cutaneous nerves may exert a minor modulatory role in depilation-induced hair growth, they are not essential for normal murine anagen development.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 574-578 |
| Number of pages | 5 |
| Journal | Archives of Dermatological Research |
| Volume | 290 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 16 1998 |
| Externally published | Yes |
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Keywords
- C57BL/6 mice
- Denervation
- Hair growth
ASJC Scopus subject areas
- Dermatology
Cite this
Intact hair follicle innervation is not essential for anagen induction and development. / Maurer, Marcus; Peters, Eva M J; Botchkarev, Vladimir A.; Paus, Ralf.
In: Archives of Dermatological Research, Vol. 290, No. 10, 16.11.1998, p. 574-578.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intact hair follicle innervation is not essential for anagen induction and development
AU - Maurer, Marcus
AU - Peters, Eva M J
AU - Botchkarev, Vladimir A.
AU - Paus, Ralf
PY - 1998/11/16
Y1 - 1998/11/16
N2 - Neuropeptides produced, stored and secreted by the unusually dense sensory and autonomic innervation of hair follicles (HFs) can induce hair growth (anagen) and may be involved in hair growth control. To test the role of follicle innervation of HF cycling in vivo, we generated innervation-deficient HFs by unilateral surgical denervation of a defined region of back skin in C57BL/6 mice and assessed its effect on spontaneous and induced anagen development. Successful denervation was demonstrated by the absence of PGP 9.5+ or tyrosine hydroxylase+ nerves and nerve-associated neuropeptides (substance P, CGRP). By quantitative histomorphometry, no significant difference in spontaneous or cyclosporin A-induced anagen development could be detected between sham-operated control skin and denervated skin. Only after hair growth induction by depilation, a discrete, marginally significant retardation of anagen development was apparent in denervated HFs. Thus, even though cutaneous nerves may exert a minor modulatory role in depilation-induced hair growth, they are not essential for normal murine anagen development.
AB - Neuropeptides produced, stored and secreted by the unusually dense sensory and autonomic innervation of hair follicles (HFs) can induce hair growth (anagen) and may be involved in hair growth control. To test the role of follicle innervation of HF cycling in vivo, we generated innervation-deficient HFs by unilateral surgical denervation of a defined region of back skin in C57BL/6 mice and assessed its effect on spontaneous and induced anagen development. Successful denervation was demonstrated by the absence of PGP 9.5+ or tyrosine hydroxylase+ nerves and nerve-associated neuropeptides (substance P, CGRP). By quantitative histomorphometry, no significant difference in spontaneous or cyclosporin A-induced anagen development could be detected between sham-operated control skin and denervated skin. Only after hair growth induction by depilation, a discrete, marginally significant retardation of anagen development was apparent in denervated HFs. Thus, even though cutaneous nerves may exert a minor modulatory role in depilation-induced hair growth, they are not essential for normal murine anagen development.
KW - C57BL/6 mice
KW - Denervation
KW - Hair growth
UR - http://www.scopus.com/inward/record.url?scp=0031725622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031725622&partnerID=8YFLogxK
U2 - 10.1007/s004030050354
DO - 10.1007/s004030050354
M3 - Article
C2 - 9836509
AN - SCOPUS:0031725622
VL - 290
SP - 574
EP - 578
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
SN - 0340-3696
IS - 10
ER -