Insurgence of Fusarium keratitis associated with contact lens wear

Eduardo C Alfonso, Jorge Cantu-Dibildox, Wuqaas M. Munir, Darlene Miller, Terrence O'Brien, Carol Karp, Sonia H Yoo, Richard Forster, William W Culbertson, Kendall Donaldson, Jill Rodila, Yunhee Lee

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Objective: To describe the clinical presentation and course of patients who developed keratitis due to Fusarium while wearing nontherapeutic soft contact lenses. Methods: A retrospective review of microbiologic records from January 1, 2004, through April 15, 2006, was performed, identifying all patients with corneal ulceration and a culture positive for Fusarium species. Medical records of 34 patients were reviewed for clinical characteristics, treatment regimens, and microbiologic features. Results: The most common antimicrobial medications administered prior to Fusarium diagnosis were antibacterials in 31 of 34 patients. No distinct preponderance of any one brand of either contact lens or solution was identified. The microbiologic corneal cultures found Fusarium oxysporum in 20 cases, Fusarium solani in 3 cases, Fusarium species not further identifiable in 10 cases, and no growth in 1 case. Patients with a delayed onset of treatment had a tendency for prolonged treatment until cure. Conclusions: Fusarium has previously been an unusual organism in the etiology of infectious keratitis in the setting of nontherapeutic soft contact lens wear. A delay in proper diagnosis and intervention may contribute to a prolonged treatment course. The microbial spectrum of contact lens-related keratitis may be evolving with higher participation of Fusarium species compared with prior reports.

Original languageEnglish
Pages (from-to)941-947
Number of pages7
JournalArchives of Ophthalmology
Volume124
Issue number7
DOIs
StatePublished - Jul 17 2006

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Keratitis
Contact Lenses
Fusarium
Hydrophilic Contact Lens
Contact Lens Solutions
Therapeutics
Medical Records
Growth

ASJC Scopus subject areas

  • Ophthalmology

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Insurgence of Fusarium keratitis associated with contact lens wear. / Alfonso, Eduardo C; Cantu-Dibildox, Jorge; Munir, Wuqaas M.; Miller, Darlene; O'Brien, Terrence; Karp, Carol; Yoo, Sonia H; Forster, Richard; Culbertson, William W; Donaldson, Kendall; Rodila, Jill; Lee, Yunhee.

In: Archives of Ophthalmology, Vol. 124, No. 7, 17.07.2006, p. 941-947.

Research output: Contribution to journalArticle

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