Abstract
Objective: To describe the clinical presentation and course of patients who developed keratitis due to Fusarium while wearing nontherapeutic soft contact lenses. Methods: A retrospective review of microbiologic records from January 1, 2004, through April 15, 2006, was performed, identifying all patients with corneal ulceration and a culture positive for Fusarium species. Medical records of 34 patients were reviewed for clinical characteristics, treatment regimens, and microbiologic features. Results: The most common antimicrobial medications administered prior to Fusarium diagnosis were antibacterials in 31 of 34 patients. No distinct preponderance of any one brand of either contact lens or solution was identified. The microbiologic corneal cultures found Fusarium oxysporum in 20 cases, Fusarium solani in 3 cases, Fusarium species not further identifiable in 10 cases, and no growth in 1 case. Patients with a delayed onset of treatment had a tendency for prolonged treatment until cure. Conclusions: Fusarium has previously been an unusual organism in the etiology of infectious keratitis in the setting of nontherapeutic soft contact lens wear. A delay in proper diagnosis and intervention may contribute to a prolonged treatment course. The microbial spectrum of contact lens-related keratitis may be evolving with higher participation of Fusarium species compared with prior reports.
| Original language | English |
|---|---|
| Pages (from-to) | 941-947 |
| Number of pages | 7 |
| Journal | Archives of Ophthalmology |
| Volume | 124 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 17 2006 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Insurgence of Fusarium keratitis associated with contact lens wear. / Alfonso, Eduardo C; Cantu-Dibildox, Jorge; Munir, Wuqaas M.; Miller, Darlene; O'Brien, Terrence; Karp, Carol; Yoo, Sonia H; Forster, Richard; Culbertson, William W; Donaldson, Kendall; Rodila, Jill; Lee, Yunhee.
In: Archives of Ophthalmology, Vol. 124, No. 7, 17.07.2006, p. 941-947.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insurgence of Fusarium keratitis associated with contact lens wear
AU - Alfonso, Eduardo C
AU - Cantu-Dibildox, Jorge
AU - Munir, Wuqaas M.
AU - Miller, Darlene
AU - O'Brien, Terrence
AU - Karp, Carol
AU - Yoo, Sonia H
AU - Forster, Richard
AU - Culbertson, William W
AU - Donaldson, Kendall
AU - Rodila, Jill
AU - Lee, Yunhee
PY - 2006/7/17
Y1 - 2006/7/17
N2 - Objective: To describe the clinical presentation and course of patients who developed keratitis due to Fusarium while wearing nontherapeutic soft contact lenses. Methods: A retrospective review of microbiologic records from January 1, 2004, through April 15, 2006, was performed, identifying all patients with corneal ulceration and a culture positive for Fusarium species. Medical records of 34 patients were reviewed for clinical characteristics, treatment regimens, and microbiologic features. Results: The most common antimicrobial medications administered prior to Fusarium diagnosis were antibacterials in 31 of 34 patients. No distinct preponderance of any one brand of either contact lens or solution was identified. The microbiologic corneal cultures found Fusarium oxysporum in 20 cases, Fusarium solani in 3 cases, Fusarium species not further identifiable in 10 cases, and no growth in 1 case. Patients with a delayed onset of treatment had a tendency for prolonged treatment until cure. Conclusions: Fusarium has previously been an unusual organism in the etiology of infectious keratitis in the setting of nontherapeutic soft contact lens wear. A delay in proper diagnosis and intervention may contribute to a prolonged treatment course. The microbial spectrum of contact lens-related keratitis may be evolving with higher participation of Fusarium species compared with prior reports.
AB - Objective: To describe the clinical presentation and course of patients who developed keratitis due to Fusarium while wearing nontherapeutic soft contact lenses. Methods: A retrospective review of microbiologic records from January 1, 2004, through April 15, 2006, was performed, identifying all patients with corneal ulceration and a culture positive for Fusarium species. Medical records of 34 patients were reviewed for clinical characteristics, treatment regimens, and microbiologic features. Results: The most common antimicrobial medications administered prior to Fusarium diagnosis were antibacterials in 31 of 34 patients. No distinct preponderance of any one brand of either contact lens or solution was identified. The microbiologic corneal cultures found Fusarium oxysporum in 20 cases, Fusarium solani in 3 cases, Fusarium species not further identifiable in 10 cases, and no growth in 1 case. Patients with a delayed onset of treatment had a tendency for prolonged treatment until cure. Conclusions: Fusarium has previously been an unusual organism in the etiology of infectious keratitis in the setting of nontherapeutic soft contact lens wear. A delay in proper diagnosis and intervention may contribute to a prolonged treatment course. The microbial spectrum of contact lens-related keratitis may be evolving with higher participation of Fusarium species compared with prior reports.
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UR - http://www.scopus.com/inward/citedby.url?scp=33745864029&partnerID=8YFLogxK
U2 - 10.1001/archopht.124.7.ecs60039
DO - 10.1001/archopht.124.7.ecs60039
M3 - Article
C2 - 16769827
AN - SCOPUS:33745864029
VL - 124
SP - 941
EP - 947
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 7
ER -