Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart

Ernesto Pretto, T. Schaible, J. Scheuer, P. Safar, S. W. Stezoski

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We used a modification of Langendorff's isolated perfused nonworking rat-heart model to study the effects of diabetes, insulin-treated diabetes, and hyperinsulinemia on left ventricular pressure, force of ventricular contraction, and myocardial contracture, before, during, and after 20 min of complete normothermic global ischemia. Untreated diabetic rat hearts behaved the same as normal hearts, but insulin-treated diabetic hearts had more ischemic and postischemic contracture (p < .01), and less return of left ventricular function. Chronic insulin treatment potentiated ischemic contracture in diabetic and nondiabetic rat hearts. These results support the hypotheses that insulin can increase Ca++ actin-myosin ATPase activity, and increase the affinity of myofibrillar receptors for calcium, which may lead to increased ischemic contracture. Insulin as a risk factor in myocardial ischemia, cardiothoracic surgery and cardiac resuscitation, and other pathogenetic factors of 'stone heart' development, deserve further investigation.

Original languageEnglish
Pages (from-to)555-559
Number of pages5
JournalCritical Care Medicine
Volume14
Issue number6
StatePublished - Aug 21 1986
Externally publishedYes

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Contracture
Myocardial Ischemia
Ischemic Contracture
Insulin
Myocardial Contraction
Calcium-Sensing Receptors
Hyperinsulinism
Ventricular Pressure
Myosins
Left Ventricular Function
Resuscitation
Thoracic Surgery
Actins
Ischemia

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Pretto, E., Schaible, T., Scheuer, J., Safar, P., & Stezoski, S. W. (1986). Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart. Critical Care Medicine, 14(6), 555-559.

Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart. / Pretto, Ernesto; Schaible, T.; Scheuer, J.; Safar, P.; Stezoski, S. W.

In: Critical Care Medicine, Vol. 14, No. 6, 21.08.1986, p. 555-559.

Research output: Contribution to journalArticle

Pretto, E, Schaible, T, Scheuer, J, Safar, P & Stezoski, SW 1986, 'Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart', Critical Care Medicine, vol. 14, no. 6, pp. 555-559.
Pretto E, Schaible T, Scheuer J, Safar P, Stezoski SW. Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart. Critical Care Medicine. 1986 Aug 21;14(6):555-559.
Pretto, Ernesto ; Schaible, T. ; Scheuer, J. ; Safar, P. ; Stezoski, S. W. / Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart. In: Critical Care Medicine. 1986 ; Vol. 14, No. 6. pp. 555-559.
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