TY - JOUR
T1 - Insulin therapy in type II diabetes
T2 - Who needs it, how much of it, and for how long?
AU - Skyler, J. S.
PY - 1997
Y1 - 1997
N2 - Insulin therapy can control glucose levels in patients with type II diabetes. Because of insulin resistance, high doses may be required initially to attain satisfactory control; however, also because of insulin resistance, hypoglycemia with insulin therapy is much less common among patients with type II diabetes than among those with type I diabetes. Insulin therapy need not be permanent. In some cases, temporary worsening of disease is the result of glucose toxicity and insulin can be discontinued or doses reduced when disease severity subsides. On the other hand, beta-cell failure is progressive, and with long duration of diabetes, permanent insulin therapy may be necessary to achieve satisfactory glucose control.
AB - Insulin therapy can control glucose levels in patients with type II diabetes. Because of insulin resistance, high doses may be required initially to attain satisfactory control; however, also because of insulin resistance, hypoglycemia with insulin therapy is much less common among patients with type II diabetes than among those with type I diabetes. Insulin therapy need not be permanent. In some cases, temporary worsening of disease is the result of glucose toxicity and insulin can be discontinued or doses reduced when disease severity subsides. On the other hand, beta-cell failure is progressive, and with long duration of diabetes, permanent insulin therapy may be necessary to achieve satisfactory glucose control.
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U2 - 10.3810/pgm.1997.02.159
DO - 10.3810/pgm.1997.02.159
M3 - Article
C2 - 9046928
AN - SCOPUS:0031029202
VL - 101
SP - 85-90+92-94+96
JO - Postgraduate Medicine
JF - Postgraduate Medicine
SN - 0032-5481
IS - 2
ER -