Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication

Marie E. Monaco, C. Kent Osborne, Marc E. Lippman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.

Original languageEnglish (US)
Pages (from-to)1591-1593
Number of pages3
JournalJournal of the National Cancer Institute
Volume58
Issue number6
DOIs
StatePublished - Jun 1977

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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