Abstract
Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.
| Original language | English |
|---|---|
| Pages (from-to) | 1591-1593 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 58 |
| Issue number | 6 |
| State | Published - Dec 1 1977 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Insulin stimulation of fatty acid synthesis in human breast cancer cells. Brief communication. / Monaco, M. E.; Kent Osborne, C.; Lippman, Marc E.
In: Journal of the National Cancer Institute, Vol. 58, No. 6, 01.12.1977, p. 1591-1593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Insulin stimulation of fatty acid synthesis in human breast cancer cells. Brief communication
AU - Monaco, M. E.
AU - Kent Osborne, C.
AU - Lippman, Marc E
PY - 1977/12/1
Y1 - 1977/12/1
N2 - Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.
AB - Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017646592&partnerID=8YFLogxK
M3 - Article
C2 - 559098
AN - SCOPUS:0017646592
VL - 58
SP - 1591
EP - 1593
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 6
ER -