Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication

Marie E. Monaco; C. Kent Osborne; Marc E. Lippman

doi:10.1093/jnci/58.6.1591

Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication

Marie E. Monaco, C. Kent Osborne, Marc E. Lippman

Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [¹⁴C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.

Original language	English (US)
Pages (from-to)	1591-1593
Number of pages	3
Journal	Journal of the National Cancer Institute
Volume	58
Issue number	6
DOIs	https://doi.org/10.1093/jnci/58.6.1591
State	Published - Jun 1977

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication",

abstract = "Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.",

author = "Monaco, {Marie E.} and Osborne, {C. Kent} and Lippman, {Marc E.}",

note = "Funding Information: ABBREVIATIONS USED: V max = maximal velocity; Km = Michaelis constant. 1 Received January 3, 1977; accepted January 13, 1977. 2 Medicine Branch, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 3 Supported in part by Public Health Service Research Fellowship 5 F32 CA05013-02 from the National Cancer Institute. 4 Address reprint requests to Dr. M. Lippman.",

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Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication

Abstract

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