Abstract
Four human breast cancer cell lines were tested for their response to hormones with respect to the lactational function, fatty acid synthesis. Physiologic concentrations of insulin enhanced the incorporation of [14C]acetate into fatty acids in 2 of 4 cell lines tested. All cell lines had specific, high-affinity insulin receptors; therefore, the failure of two lines to respond could not be attributed to the absence of receptor. The effect of insulin involved an increase in the maximum velocity of incorporation rather than a decrease in the Michaelis constant.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1591-1593 |
| Number of pages | 3 |
| Journal | Journal of the National Cancer Institute |
| Volume | 58 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1977 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Monaco, M. E., Osborne, C. K., & Lippman, M. E. (1977). Insulin stimulation of fatty acid synthesis in human breast cancer cells: Brief communication. Journal of the National Cancer Institute, 58(6), 1591-1593. https://doi.org/10.1093/jnci/58.6.1591