Insulin sensitivity and blood pressure

Jay S. Skyler, Jennifer B. Marks, Novelette E. Thompson, Michael D. Fili, Neil Schneiderman

Research output: Chapter in Book/Report/Conference proceedingChapter


Hypertension, glucose intolerance, obesity, and hyperlipidemia are extremely prevalent problems in Western society, and each confers increased risk for coronary heart disease (CHD; Donahue, Skyler, Schneiderman, & Prineas, 1990). This cluster of disorders is so commonly associated as to suggest common pathogenetic mechanisms. Hyperinsulinemia and insulin resistance have been proposed to be the underlying link between these disorders (Christlieb, Krolewski, Warram, & Soeldner, 1985; Donahue et al., 1990; Ferrari & Weidmann, 1990; Krieger & Landsberg, 1988; Reaven & Hoffman, 1987; Sims, 1982; Swislocki, 1990), which collectively have been dubbed the GOH (glucose intolerance–obesity–hypertension) syndrome by Modan et al. (1985), "Syndrome X" by Reaven (1988), the "deadly quartet" by Kaplan (1989), the "chronic disease risk factor syndrome" by Zimmet (1989), and the "insulin resistance syndrome" by DeFronzo and Ferrannini (1990).

Original languageEnglish (US)
Title of host publicationStress and Disease Processes
Subtitle of host publicationPerspectives in Behavioral Medicine
PublisherTaylor and Francis
Number of pages27
ISBN (Electronic)9781317844044
ISBN (Print)0805811613, 9780805811612
StatePublished - Jan 1 2018

ASJC Scopus subject areas

  • Psychology(all)


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